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Nutrients 2018, 10(8), 1117;

Food Consumption as a Modifier of the Association between LEPR Gene Variants and Excess Body Weight in Children and Adolescents: A Study of the SCAALA Cohort

Departamento Ciência da Nutrição, Escola de Nutrição, Universidade Federal da Bahia, Av. Araújo Pinho, 32, Canela, CEP: 40.110-150, Salvador, BA Brasil
Instituto Gonçalo Moniz (IGM), Fundação Osvaldo Cruz—FIOCRUZ-Bahia, Av. Waldemar Falcão, 121, Candeal-Salvador/BA, CEP: 40296-710, Salvador, BA, Brasil
UNIFACS—Universidade Salvador, Laureate International Universities, Rua Doutor José Peroba, 251, Edf. Civil Empresarial, Sobreloja, STIEP, CEP: 41770-235, Salvador, BA, Brasil
Departamento de Ciências da Biorregulação, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Av. Reitor Miguel Calmon. s/n, Vale do Canela, CEP: 40110-100, Salvador, BA, Brasil
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine (LSHTM), Keppel Street, London, WC1E 7HT UK
Instituto de Saúde Coletiva, Universidade Federal da Bahia, Rua Basílio da Gama, s/n, Canela, CEP:40.110-040, Salvador, BA, Brasil
Instituto de Matemática, Universidade Federal da Bahia-Av. Adhemar de Barros, s/n-Ondina, CEP: 40.170-110, Salvador, BA, Brasil
Cidacs—Centro de Integração de Dados e Conhecimentos para Saúde, Instituo Gonçalo Muniz, Fundação Owaldo Cruz, Ministério da Saúde, Parque Tecnológico da Bahia, Rua Mundo, 121, Trobogy, CEP: 41745-715, Salvador, BA, Brasil
Observatório de Epidemiologia Nutricional, Departamento de Nutrição Aplicada e Social, Instituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro-UERJ. CEP: 21941-590, Rio de Janeiro, RJ, Brasil
Center for Global Health & Diseases, Biomedical Research Building (BRB), Room 425, Case Western Reserve University, 2109 Adelbert Rd, Cleveland, OH 44106, USA
Author to whom correspondence should be addressed.
Received: 12 July 2018 / Revised: 4 August 2018 / Accepted: 8 August 2018 / Published: 18 August 2018
(This article belongs to the Special Issue Nutrigenomics)
Full-Text   |   PDF [308 KB, uploaded 18 August 2018]


No studies showing that food consumption is a modifier of the association of variants of the leptin receptor gene (LEPR) with body weight have involved a Brazilian population. The aim of this study was to evaluate the modifying effect of dietary intake on the association between the LEPR gene and excess weight. In this study, 1211 children and adolescents aged 4–11 years were assessed. Participants were genotyped for 112 single-nucleotide variants of the LEPR gene. Anthropometric measurements were performed, and dietary data were obtained. Logistic regressions were used to study the associations of interest. Of the participants, 13.4% were overweight/obese. The risk allele (G) of the rs1137100 variant was associated with excess weight in individuals with fat consumption below the median (odds ratio OR = 1.92; 95% confidence interval CI = 1.18–3.14), with daily frequency of consumption of drink/artificial juice (OR = 2.15; 95% CI = 1.26–3.68) and refined cereals (OR = 2.17; 95% CI = 1.31–3.62) above the median. The risk allele (G) of variant rs1177681 was also associated with excess weight (OR = 2.74; 95% CI = 1.65–4.57) in subjects with a daily frequency of refined cereal consumption above the median. The association between LEPR and excess weight can be modulated by the type and distribution of dietary fatty acids, sugary drinks, and refined cereals. View Full-Text
Keywords: overweight; obesity; leptin receptor gene; children and adolescents; food consumption overweight; obesity; leptin receptor gene; children and adolescents; food consumption
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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dos Santos Rocha, A.; de Cássia Ribeiro-Silva, R.; Nunes de Oliveira Costa, G.; Alexandrina Figueiredo, C.; Cunha Rodrigues, L.; Maria Alvim Matos, S.; Leovigildo Fiaccone, R.; Oliveira, P.R.; Alves-Santos, N.H.; Blanton, R.E.; Lima Barreto, M. Food Consumption as a Modifier of the Association between LEPR Gene Variants and Excess Body Weight in Children and Adolescents: A Study of the SCAALA Cohort. Nutrients 2018, 10, 1117.

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