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Nutrients 2018, 10(7), 892; https://doi.org/10.3390/nu10070892

Celiac Disease and Liver Disorders: From Putative Pathogenesis to Clinical Implications

1
Centre for Research on Nutrition, Metabolism and Diabetes, Third Faculty of Medicine, Charles University, Ruska 87, 100 00 Prague, Czech Republic
2
Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Ruska 87, 100 00 Prague, Czech Republic
3
Laboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences, v.v.i., Videnska 1083, 142 20 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Received: 24 May 2018 / Revised: 4 July 2018 / Accepted: 10 July 2018 / Published: 12 July 2018
(This article belongs to the Special Issue Extraintestinal Manifestations of Coeliac Disease)
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Abstract

Immunologically mediated liver diseases belong to the common extraintestinal manifestations of celiac disease. We have reviewed the current literature that addresses the association between celiac disease and liver disorders. We searched relevant articles on MEDLINE/PubMed up to 15 June 2018. The objective of the article is to provide a comprehensive and up-to-date review on the latest hypotheses explaining the pathogenetic relationship between celiac disease and liver injury. Besides the involvement of gut–liver axis, tissue transglutaminase antibodies, and impairment of intestinal barrier, we integrate the latest achievements made in elucidation of the role of gut microbiota in celiac disease and liver disorders, that has not yet been sufficiently discussed in the literature in this context. The further objective is to provide a complete clinical overview on the types of liver diseases frequently found in celiac disease. In conclusion, the review highlights the clinical implication, recommend a rational approach for managing elevated transaminases in celiac patients, and underscore the importance of screening for celiac disease in patients with associated liver disease. View Full-Text
Keywords: autoimmunity; celiac hepatitis; gut–liver axis; liver immunity; non-alcoholic fatty liver disease; tolerance; intestinal barrier autoimmunity; celiac hepatitis; gut–liver axis; liver immunity; non-alcoholic fatty liver disease; tolerance; intestinal barrier
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Hoffmanová, I.; Sánchez, D.; Tučková, L.; Tlaskalová-Hogenová, H. Celiac Disease and Liver Disorders: From Putative Pathogenesis to Clinical Implications. Nutrients 2018, 10, 892.

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