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Nutrients 2018, 10(8), 1015; https://doi.org/10.3390/nu10081015

Extraintestinal Manifestations of Celiac Disease: Early Detection for Better Long-Term Outcomes

1
Celiac Disease Research Center, Faculty of Medicine and Life Sciences, University of Tampere, 33014 Tampere, Finland
2
Department of Internal Medicine, Hospital District of South Ostrobothnia, 60200 Seinäjoki, Finland
3
Tampere Center for Child Health Research, Tampere University Hospital and University of Tampere, 33014 Tampere, Finland
*
Author to whom correspondence should be addressed.
Received: 1 July 2018 / Revised: 25 July 2018 / Accepted: 31 July 2018 / Published: 3 August 2018
(This article belongs to the Special Issue Extraintestinal Manifestations of Coeliac Disease)
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Abstract

Population-based screening studies have shown celiac disease to be one of the most common chronic gastrointestinal diseases. Nevertheless, because of the diverse clinical presentation, the great majority of patients remain unrecognized. Particularly difficult to identify are the multifaceted extraintestinal symptoms that may appear at variable ages. Although the pathogenesis and long-term outcome of these manifestations are still poorly established, there is some evidence that unrecognized celiac disease predisposes to severe complications if not diagnosed and prevented with an early-initiated gluten-free diet. Therefore, it is of utmost importance that physicians of different disciplines learn to recognize celiac disease in individuals with non-gastrointestinal symptoms. In the future, more studies are needed to clarify the factors affecting development and prognosis of the extraintestinal manifestations. View Full-Text
Keywords: celiac disease; extraintestinal; recognition; diagnosis; clinical presentation; gluten-free diet; prognosis celiac disease; extraintestinal; recognition; diagnosis; clinical presentation; gluten-free diet; prognosis
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Laurikka, P.; Nurminen, S.; Kivelä, L.; Kurppa, K. Extraintestinal Manifestations of Celiac Disease: Early Detection for Better Long-Term Outcomes. Nutrients 2018, 10, 1015.

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