Next Article in Journal
Buckwheat and CVD Risk Markers: A Systematic Review and Meta-Analysis
Next Article in Special Issue
Pilot Study Examining the Influence of Potassium Bicarbonate Supplementation on Nitrogen Balance and Whole-Body Ammonia and Urea Turnover Following Short-Term Energy Restriction in Older Men
Previous Article in Journal
Growth Hormone Secretion Patterns in German Landrace (DL) Fetuses and Piglets Compared to DL Piglets with Inherited 1,25-Dihydroxyvitamin D3 Deficiency
Previous Article in Special Issue
Kidney Response to the Spectrum of Diet-Induced Acid Stress
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessReview
Nutrients 2018, 10(5), 618; https://doi.org/10.3390/nu10050618

Insulin Sensitivity and Glucose Homeostasis Can Be Influenced by Metabolic Acid Load

1
Laboratory of Dietetics and Clinical Nutrition Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy
2
Department of Biology, Center for Obesity Reversal, Georgia State University, Atlanta, GA 30302, USA
*
Author to whom correspondence should be addressed.
Received: 30 March 2018 / Revised: 8 May 2018 / Accepted: 10 May 2018 / Published: 15 May 2018
(This article belongs to the Special Issue Nutritional Prevention and Acid Base Status)
View Full-Text   |   Download PDF [529 KB, uploaded 15 May 2018]   |  

Abstract

Recent epidemiological findings suggest that high levels of dietary acid load can affect insulin sensitivity and glucose metabolism. Consumption of high protein diets results in the over-production of metabolic acids which has been associated with the development of chronic metabolic disturbances. Mild metabolic acidosis has been shown to impair peripheral insulin action and several epidemiological findings suggest that metabolic acid load markers are associated with insulin resistance and impaired glycemic control through an interference intracellular insulin signaling pathways and translocation. In addition, higher incidence of diabetes, insulin resistance, or impaired glucose control have been found in subjects with elevated metabolic acid load markers. Hence, lowering dietary acid load may be relevant for improving glucose homeostasis and prevention of type 2 diabetes development on a long-term basis. However, limitations related to patient acid load estimation, nutritional determinants, and metabolic status considerably flaws available findings, and the lack of solid data on the background physiopathology contributes to the questionability of results. Furthermore, evidence from interventional studies is very limited and the trials carried out report no beneficial results following alkali supplementation. Available literature suggests that poor acid load control may contribute to impaired insulin sensitivity and glucose homeostasis, but it is not sufficiently supportive to fully elucidate the issue and additional well-designed studies are clearly needed. View Full-Text
Keywords: insulin resistance; diabetes; metabolism; metabolic acidosis; glucose homeostasis; dietary acid load; western diet; acid–base insulin resistance; diabetes; metabolism; metabolic acidosis; glucose homeostasis; dietary acid load; western diet; acid–base
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Della Guardia, L.; Thomas, M.A.; Cena, H. Insulin Sensitivity and Glucose Homeostasis Can Be Influenced by Metabolic Acid Load. Nutrients 2018, 10, 618.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top