Kidney Response to the Spectrum of Diet-Induced Acid Stress
AbstractChronic ingestion of the acid (H+)-producing diets that are typical of developed societies appears to pose a long-term threat to kidney health. Mechanisms employed by kidneys to excrete this high dietary H+ load appear to cause long-term kidney injury when deployed over many years. In addition, cumulative urine H+ excretion is less than the cumulative increment in dietary H+, consistent with H+ retention. This H+ retention associated with the described high dietary H+ worsens as the glomerular filtration rate (GFR) declines which further exacerbates kidney injury. Modest H+ retention does not measurably change plasma acid–base parameters but, nevertheless, causes kidney injury and might contribute to progressive nephropathy. Current clinical methods do not detect H+ retention in its early stages but the condition manifests as metabolic acidosis as it worsens, with progressive decline of the glomerular filtration rate. We discuss this spectrum of H+ injury, which we characterize as “H+ stress”, and the emerging evidence that high dietary H+ constitutes a threat to long-term kidney health. View Full-Text
Share & Cite This Article
Goraya, N.; Wesson, D.E. Kidney Response to the Spectrum of Diet-Induced Acid Stress. Nutrients 2018, 10, 596.
Goraya N, Wesson DE. Kidney Response to the Spectrum of Diet-Induced Acid Stress. Nutrients. 2018; 10(5):596.Chicago/Turabian Style
Goraya, Nimrit; Wesson, Donald E. 2018. "Kidney Response to the Spectrum of Diet-Induced Acid Stress." Nutrients 10, no. 5: 596.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.