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Nutrients 2018, 10(5), 604; https://doi.org/10.3390/nu10050604

Inflammation, not Cholesterol, Is a Cause of Chronic Disease

Department of Biological Sciences, University of Limerick, V94 T9PX Limerick, Ireland
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Received: 23 April 2018 / Revised: 3 May 2018 / Accepted: 9 May 2018 / Published: 12 May 2018
(This article belongs to the Special Issue Dietary Cholesterol:Is It Related to Chronic Disease)
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Abstract

Since the Seven Countries Study, dietary cholesterol and the levels of serum cholesterol in relation to the development of chronic diseases have been somewhat demonised. However, the principles of the Mediterranean diet and relevant data linked to the examples of people living in the five blue zones demonstrate that the key to longevity and the prevention of chronic disease development is not the reduction of dietary or serum cholesterol but the control of systemic inflammation. In this review, we present all the relevant data that supports the view that it is inflammation induced by several factors, such as platelet-activating factor (PAF), that leads to the onset of cardiovascular diseases (CVD) rather than serum cholesterol. The key to reducing the incidence of CVD is to control the activities of PAF and other inflammatory mediators via diet, exercise, and healthy lifestyle choices. The relevant studies and data supporting these views are discussed in this review. View Full-Text
Keywords: cardiovascular disease; atherosclerosis; inflammation; platelet-activating factor; oxidised lipoproteins; cholesterol; chronic diseases cardiovascular disease; atherosclerosis; inflammation; platelet-activating factor; oxidised lipoproteins; cholesterol; chronic diseases
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Tsoupras, A.; Lordan, R.; Zabetakis, I. Inflammation, not Cholesterol, Is a Cause of Chronic Disease. Nutrients 2018, 10, 604.

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