Selected Physiological Effects of a Garcinia Gummi-Gutta Extract in Rats Fed with Different Hypercaloric Diets
AbstractGarcinia gummi-gutta (GGG) rind extract is effective for reducing appetite, body weight and adiposity of obese rodents fed high-fat (HF), high-sugar (HS) or high fat/sugar (HFS)-based diets, but these effects have not been simultaneously evaluated. Thirty obese (~425 g) male Wistar rats were fed for eleven weeks with six hypercaloric diets (4.1 kcal/g; five rats/diet) non-supplemented (HF, HS, HFS), or supplemented (HF+, HS+, HFS+) with GGG extract (5.9%), while rats from the control group (375 g) were fed a normocaloric diet (3.5 kcal/g). Body weight, dietary intake, body fat distribution, and histological and biochemical parameters were recorded. Compared to control rats, non-supplemented and supplemented groups consumed significantly less food (14.3% and 24.6% (−4.3 g/day), respectively) (p < 0.05). Weight loss was greater in the HF+ group (35–52 g), which consumed 1.9 times less food than the HS+ or HFS+ fed groups. The HF and HFS groups showed 40% less plasma triacylglycerides and lower glucose levels compared to the HF+. GGG-supplemented diets were associated with lower ketonuria. The HF+ diet was associated with the best anti-adiposity effect (as measured with the dual X-ray absorptiometry (DXA) and Soxhlet methods). The severity of hepatocyte lipidosis was HF > control > HF+, and no signs of toxicity in the testes were observed. The results indicate that GGG is more effective when co-administered with HF diets in obese rats. View Full-Text
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Guillén-Enríquez, C.; Lopez-Teros, V.; Martín-Orozco, U.; López-Díaz, J.A.; del Hierro-Ochoa, J.; Ramos-Jiménez, A.; Astiazarán-García, H.; Martínez-Ruiz, N.R.; Wall-Medrano, A. Selected Physiological Effects of a Garcinia Gummi-Gutta Extract in Rats Fed with Different Hypercaloric Diets. Nutrients 2018, 10, 565.
Guillén-Enríquez C, Lopez-Teros V, Martín-Orozco U, López-Díaz JA, del Hierro-Ochoa J, Ramos-Jiménez A, Astiazarán-García H, Martínez-Ruiz NR, Wall-Medrano A. Selected Physiological Effects of a Garcinia Gummi-Gutta Extract in Rats Fed with Different Hypercaloric Diets. Nutrients. 2018; 10(5):565.Chicago/Turabian Style
Guillén-Enríquez, Carolina; Lopez-Teros, Veronica; Martín-Orozco, Ubicelio; López-Díaz, José A.; del Hierro-Ochoa, Julio; Ramos-Jiménez, Arnulfo; Astiazarán-García, Humberto; Martínez-Ruiz, Nina R.; Wall-Medrano, Abraham. 2018. "Selected Physiological Effects of a Garcinia Gummi-Gutta Extract in Rats Fed with Different Hypercaloric Diets." Nutrients 10, no. 5: 565.
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