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Nutrients 2018, 10(5), 558; https://doi.org/10.3390/nu10050558

Assessment of Lactose-Free Diet on the Phalangeal Bone Mineral Status in Italian Adolescents Affected by Adult-Type Hypolactasia

Department of Medical Sciences, Section of Pediatrics, University of Ferrara, Via A. Moro 8, 44124 Ferrara, Italy
These authors equally contributed.
Present address: Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
*
Author to whom correspondence should be addressed.
Received: 27 March 2018 / Revised: 25 April 2018 / Accepted: 26 April 2018 / Published: 1 May 2018
(This article belongs to the Special Issue Nutrition in Pediatric Gastroenterology: Selected Papers from SIGENP)
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Abstract

Adult-type hypolactasia (ATH) is a clinical syndrome of primary lactase deficiency. A lactose-free diet is advisable to avoid the symptoms linked to the condition, but this potentially creates problems for optimal bone mineralization due to reduced calcium intake. To evaluate the effect of the lactose-free diet on the bone mineral status (BMS), we compared the phalangeal BMS of adolescents with ATH to that of peers on a normal diet. Also, we analyzed the correlations between BMS and dietary behavior, physical exercise, and calcium and vitamin D intake. A total of 102 cases and 102 healthy controls filled out a diet record and underwent phalangeal Quantitative Ultrasound (QUS). No difference in BMS was observed. The time spent on lactose-free diet (4.8 ± 3.1 years) was inversely correlated to the BMS. More than 98% of cases consumed lactose-free milk, but calcium and vitamin D intake were significantly lower. Calcium intake was correlated to physical exercise but not to BMS. Our results suggest that a lactose-free diet does not affect the phalangeal BMS of adolescents with primary lactase deficiency when their diet includes lactose-free cow’s milk. However, there is still a significantly lower calcium intake than in the population reference. The inverse correlation observed between the BMS and the time spent on a lactose-free diet suggests that a long-term follow-up is advisable. View Full-Text
Keywords: phalangeal quantitative ultrasound; lactose intolerance; calcium intake; lactose-free milk phalangeal quantitative ultrasound; lactose intolerance; calcium intake; lactose-free milk
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Baldan, A.; Tagliati, S.; Saccomandi, D.; Brusaferro, A.; Busoli, L.; Scala, A.; Malaventura, C.; Maggiore, G.; Borgna-Pignatti, C. Assessment of Lactose-Free Diet on the Phalangeal Bone Mineral Status in Italian Adolescents Affected by Adult-Type Hypolactasia. Nutrients 2018, 10, 558.

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