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Special Issue "Nutrition in Pediatric Gastroenterology: Selected Papers from SIGENP"

A special issue of Nutrients (ISSN 2072-6643).

Deadline for manuscript submissions: 31 March 2018

Special Issue Editors

Guest Editor
Prof. Dr. Carlo Catassi

Head, Department of Pediatrics, Università Politecnica delle Marche, Ancona, Italy; Past President, Italian Society for Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP)
E-Mail
Phone: +39 071 596 23 64 / +39 349 22 35 447
Fax: +39 071 36281
Interests: celiac disease; gluten-related disorders; gluten sensitivity; pediatric gastroenterology; pediatric nutrition
Guest Editor
Prof. Dr. Carlo Agostoni

Clinica Pediatrica, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico, Dipartimento di Scienze Cliniche e di Comunità, Università di Milano, Via della Commenda 9, 20122 Milan, Italy
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Phone: +39 02 55032497
Interests: fatty acids; nutrition and metabolism in disease; energy expenditure; later effects of early nutrition; systematic reviews in infant and pediatric nutrition

Special Issue Information

Dear Colleagues,

Pediatric Gastroenterology (GE) is one of the most important subspecialty areas in the field of childhood diseases, due to the large number of conditions affecting the intestinal tract, the high prevalence of these disorders in the pediatric population, and the possible impact on childhood mortality, morbidity and quality of life. The pediatric GE scenario ranges from severe conditions such as congenital microvillus atrophy or chronic intestinal pseudo obstruction requiring total parenteral nutrition or intestinal transplant, to chronic disorders affecting the quality of life, such as inflammatory bowel diseases (IBD) and celiac disease (CD) to highly prevalent conditions such as irritable bowel syndrome (IBS) or functional constipation.

Due to the unique interaction between ingested nutrients, the intestinal microbiota and the digestive tract, such as the colonocyte trophic effect of short chain fatty acids (SCFA) produced by intestinal bacteria from dietary fiber, nutrition has a special role in intestinal diseases, that goes well beyond the mere support of energy, macro- and micro-nutrients. For example, an “anti-inflammatory” diet to treat IBDs is currently under scrutiny. Food itself may be the elective cause and treatment of the disease, such as food allergy, a disorder that is particularly common in infants and children due to the immaturity of the intestinal immune system and barrier function. 

This Special Issue originates from the collaboration between Nutrients and the Italian Society for Pediatric Gastroenterology Hepatology and Nutrition (SIGENP), one of the most active organization in the Italian pediatric setting, which is well known for many important scientific contributions and collaborative studies. This Special Issue will accept original articles and reviews from authors with interest on the physiological, pathogenic and therapeutic role of nutrition in pediatric gastroenterology, including nutrition of the healthy infant and child, eating disorders, and artificial (enteral and parenteral) nutrition.

Prof. Dr. Carlo Catassi
Prof. Dr. Carlo Agostoni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pediatric gastroenterology
  • pediatric nutrition
  • nutritional therapy
  • artificial nutrition
  • eating disorders

Published Papers (2 papers)

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Research

Open AccessArticle Effectiveness and Safety of a Probiotic-Mixture for the Treatment of Infantile Colic: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial with Fecal Real-Time PCR and NMR-Based Metabolomics Analysis
Nutrients 2018, 10(2), 195; doi:10.3390/nu10020195
Received: 14 January 2018 / Revised: 5 February 2018 / Accepted: 7 February 2018 / Published: 10 February 2018
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Abstract
Introduction: To investigate the effectiveness and the safety of a probiotic-mixture (Vivomixx®, Visbiome®, DeSimone Formulation®; Danisco-DuPont, Madison, WI, USA) for the treatment of infantile colic in breastfed infants, compared with a placebo. Methods: A randomized, double-blind, placebo-controlled
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Introduction: To investigate the effectiveness and the safety of a probiotic-mixture (Vivomixx®, Visbiome®, DeSimone Formulation®; Danisco-DuPont, Madison, WI, USA) for the treatment of infantile colic in breastfed infants, compared with a placebo. Methods: A randomized, double-blind, placebo-controlled trial was conducted in exclusively breastfed infants with colic, randomly assigned to receive a probiotic-mixture or a placebo for 21 days. A structured diary of gastrointestinal events of the infants was given to the parents to complete. Samples of feces were also collected to evaluate microbial content and metabolome using fecal real-time polymerase chain reaction (qPCR) and Nuclear magnetic resonance (NMR)-based analysis. Study registered at ClinicalTrials.gov (NCT01869426). Results: Fifty-three exclusively-breastfed infants completed three weeks of treatment with a probiotic-mixture (n = 27) or a placebo (n = 26). Infants receiving the probiotic-mixture had less minutes of crying per day throughout the study by the end of treatment period (68.4 min/day vs. 98.7 min/day; p = 0.001). A higher rate of infants from the probiotic-mixture group responded to treatment (defined by reduction of crying times of ≥50% from baseline), on day 14, 12 vs. 5 (p = 0.04) and on day 21, 26 vs. 17 (p = 0.001). A higher quality of life, assessed by a 10-cm visual analogue scale, was reported by parents of the probiotic-mixture group on day 14, 7.1 ± 1.2 vs. 7.7 ± 0.9 (p = 0.02); and on day 21, 6.7 ± 1.6 vs. 5.9 ± 1.0 (p = 0.001). No differences between groups were found regarding anthropometric data, bowel movements, stool consistency or microbiota composition. Probiotics were found to affect the fecal molecular profile. No adverse events were reported. Conclusions: Administration of a probiotic-mixture appears safe and reduces inconsolable crying in exclusively breastfed infants. Full article
(This article belongs to the Special Issue Nutrition in Pediatric Gastroenterology: Selected Papers from SIGENP)
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Open AccessArticle Pediatric Chronic Intestinal Failure in Italy: Report from the 2016 Survey on Behalf of Italian Society for Gastroenterology, Hepatology and Nutrition (SIGENP)
Nutrients 2017, 9(11), 1217; doi:10.3390/nu9111217
Received: 9 October 2017 / Revised: 25 October 2017 / Accepted: 27 October 2017 / Published: 5 November 2017
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Abstract
Background: Intestinal failure (IF) is the reduction in functioning gut mass below the minimal level necessary for adequate digestion and absorption of nutrients and fluids for weight maintenance in adults or for growth in children. There is a paucity of epidemiologic data on
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Background: Intestinal failure (IF) is the reduction in functioning gut mass below the minimal level necessary for adequate digestion and absorption of nutrients and fluids for weight maintenance in adults or for growth in children. There is a paucity of epidemiologic data on pediatric IF. The purpose of this study was to determine the prevalence, incidence, regional distribution and underlying diagnosis of pediatric chronic IF (CIF) requiring home parenteral nutrition (HPN) in Italy. Methods: Local investigators were selected in 19 Italian centers either of reference for pediatric HPN or having pediatric gastroenterologists or surgeons on staff and already collaborating with the Italian Society for Pediatric Gastroenterology, Hepatology and Nutrition with regard to IF. Data requested in this survey for children at home on Parenteral Nutrition (PN) on 1 December 2016 included patient initials, year of birth, gender, family’s place of residence and underlying diagnosis determining IF. Results: We recorded 145 CIF patients on HPN aged ≤19 years. The overall prevalence was 14.12/million inhabitants (95% CI: 9.20–18.93); the overall incidence was 1.41/million inhabitant years (95% CI: 0.53–2.20). Conclusion: Our survey provides new epidemiological data on pediatric CIF in Italy; these data may be quantitatively useful in developing IF care strategy plans in all developed countries. Full article
(This article belongs to the Special Issue Nutrition in Pediatric Gastroenterology: Selected Papers from SIGENP)
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