Next Article in Journal
Maternal Vitamin D Status and Infant Infection
Previous Article in Journal
Carbohydrate Counting in Children and Adolescents with Type 1 Diabetes
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Nutrients 2018, 10(1), 110; https://doi.org/10.3390/nu10010110

Anti-Inflammatory Effects of a Stauntonia hexaphylla Fruit Extract in Lipopolysaccharide-Activated RAW-264.7 Macrophages and Rats by Carrageenan-Induced Hind Paw Swelling

Jeonnam Institute of Natural Resources Research, Jangheung-gun, Jeollanamdo 59338, Korea
*
Author to whom correspondence should be addressed.
Received: 22 November 2017 / Revised: 12 January 2018 / Accepted: 16 January 2018 / Published: 22 January 2018
View Full-Text   |   Download PDF [2912 KB, uploaded 24 January 2018]   |  

Abstract

The fruit of Stauntonia hexaphylla is commonly used as a traditional anthelmintic in Korea, Japan, and China. However, its anti-inflammatory activity and the underlying mechanisms have not been studied systematically. In the present study, we examined the anti-inflammatory activities of an aqueous extract of S. hexaphylla fruit (SHF) in lipopolysaccharide (LPS)-activated RAW 264.7 cells. The SHF extract contained anti-inflammatory compounds, such as neochlorogenic acid, chlorogenic acid, and cryptochlorogenic acid. The extract inhibited protein levels of inducible nitric oxide synthase and the activity of cyclooxygenase enzyme, with concomitant reductions in the production of nitric oxide and prostaglandin E2 in LPS-activated RAW 264.7 cells. Additionally, the SHF extract reduced the production of pro-inflammatory cytokines, including tumor necrosis factor-α, interleukin (IL)-1β, and IL-6. The SHF extract attenuated LPS-induced nuclear factor-κB (NF-κB) activation by decreasing the phosphorylation of its inhibitor, IκBα. Furthermore, the SHF extract showed a significant anti-inflammatory effect in vivo by reducing the volume of carrageenan-induced paw edema in rats. Our results suggest that the SHF extract exerts potential anti-inflammatory properties against LPS-activated RAW 254.7 cells, and in an animal model of inflammation. View Full-Text
Keywords: Stauntonia hexaphylla; anti-inflammatory; NF-κB; neochlorogenic acid; cryptochlorogenic acid; chlorogenic acid; carrageenan-induced paw edema Stauntonia hexaphylla; anti-inflammatory; NF-κB; neochlorogenic acid; cryptochlorogenic acid; chlorogenic acid; carrageenan-induced paw edema
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Kim, J.; Kim, H.; Choi, H.; Jo, A.; Kang, H.; Yun, H.; Choi, C.; Im, S. Anti-Inflammatory Effects of a Stauntonia hexaphylla Fruit Extract in Lipopolysaccharide-Activated RAW-264.7 Macrophages and Rats by Carrageenan-Induced Hind Paw Swelling. Nutrients 2018, 10, 110.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top