Table of Contents
Nutrients, Volume 10, Issue 1 (January 2018)
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Cover Story (view full-size image) Inflammatory bowel disease (IBD) of which ulcerative colitis and Crohn’s disease are the two [...] Read more. Inflammatory bowel disease (IBD) of which ulcerative colitis and Crohn’s disease are the two prevailing subtypes, is a chronic disorder with increasing worldwide incidence and prevalence rates affecting up to 0.5 % of the population in some countries. Anaemia due to iron deficiency is the most common extraintestinal manifestation among these patients. Chronic inflammation impairs duodenal iron uptake via induction of hepcidin expression in the liver, although pro-inflammatory cytokines also have a negative impact on the duodenal iron uptake. Additionally, loss of appetite during flaring disease along with certain medications used to control IBD might also have a negative influence on iron absorption. To overcome iron deficiency and resulting anaemia supplementation with either oral (cheap) or intravenous (costly and effective) iron may be useful therapeutic options. View this paper