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Pharmaceutics 2013, 5(4), 508-524; doi:10.3390/pharmaceutics5040508
Article

Influence of Sodium Lauryl Sulfate and Tween 80 on Carbamazepine–Nicotinamide Cocrystal Solubility and Dissolution Behaviour

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Received: 6 August 2013; in revised form: 5 September 2013 / Accepted: 29 September 2013 / Published: 11 October 2013
(This article belongs to the Special Issue Solid State Chemistry of Drugs)
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Abstract: The influence of the surfactants of sodium lauryl sulfate (SLS) and Tween 80 on carbamazepine–nicotinamide (CBZ–NIC) cocrystal solubility and dissolution behaviour has been studied in this work. The solubility of the CBZ–NIC cocrystal was determined by measuring the eutectic concentrations of the drug and the coformer. Evolution of the intrinsic dissolution rate (IDR) of the CBZ–NIC cocrystal was monitored by the UV imaging dissolution system during dissolution. Experimental results indicated that SLS and Tween 80 had little influence upon the solubility of the CBZ–NIC cocrystal but they had totally opposite effects on the IDR of the CBZ–NIC cocrystal during dissolution. SLS significantly increased the IDR of the CBZ–NIC cocrystal while Tween 80 decreased its IDR.
Keywords: surfactant; carbamazepine–nicotinamide cocrystal; UV imaging; intrinsic dissolution rate; Raman spectroscopy surfactant; carbamazepine–nicotinamide cocrystal; UV imaging; intrinsic dissolution rate; Raman spectroscopy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Li, M.; Qiao, N.; Wang, K. Influence of Sodium Lauryl Sulfate and Tween 80 on Carbamazepine–Nicotinamide Cocrystal Solubility and Dissolution Behaviour. Pharmaceutics 2013, 5, 508-524.

AMA Style

Li M, Qiao N, Wang K. Influence of Sodium Lauryl Sulfate and Tween 80 on Carbamazepine–Nicotinamide Cocrystal Solubility and Dissolution Behaviour. Pharmaceutics. 2013; 5(4):508-524.

Chicago/Turabian Style

Li, Mingzhong; Qiao, Ning; Wang, Ke. 2013. "Influence of Sodium Lauryl Sulfate and Tween 80 on Carbamazepine–Nicotinamide Cocrystal Solubility and Dissolution Behaviour." Pharmaceutics 5, no. 4: 508-524.


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