Pharmaceutics 2013, 5(3), 498-507; doi:10.3390/pharmaceutics5030498
Review

Advances in Lipid Nanoparticles for siRNA Delivery

Received: 1 July 2013; in revised form: 4 September 2013 / Accepted: 12 September 2013 / Published: 18 September 2013
(This article belongs to the Special Issue Liposome Technologies)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Technological advances in both siRNA (small interfering RNA) and whole genome sequencing have demonstrated great potential in translating genetic information into siRNA-based drugs to halt the synthesis of most disease-causing proteins. Despite its powerful promises as a drug, siRNA requires a sophisticated delivery vehicle because of its rapid degradation in the circulation, inefficient accumulation in target tissues and inability to cross cell membranes to access the cytoplasm where it functions. Lipid nanoparticle (LNP) containing ionizable amino lipids is the leading delivery technology for siRNA, with five products in clinical trials and more in the pipeline. Here, we focus on the technological advances behind these potent systems for siRNA-mediated gene silencing.
Keywords: lipid nanoparticle; siRNA; ionizable amino lipid; pKa; PEG lipid; targeting
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MDPI and ACS Style

Tam, Y.Y.C.; Chen, S.; Cullis, P.R. Advances in Lipid Nanoparticles for siRNA Delivery. Pharmaceutics 2013, 5, 498-507.

AMA Style

Tam YYC, Chen S, Cullis PR. Advances in Lipid Nanoparticles for siRNA Delivery. Pharmaceutics. 2013; 5(3):498-507.

Chicago/Turabian Style

Tam, Yuen Y.C.; Chen, Sam; Cullis, Pieter R. 2013. "Advances in Lipid Nanoparticles for siRNA Delivery." Pharmaceutics 5, no. 3: 498-507.

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