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Pharmaceutics 2013, 5(4), 525-541; doi:10.3390/pharmaceutics5040525

Liposome Formulation of Fullerene-Based Molecular Diagnostic and Therapeutic Agents

Luna Innovations Inc., 521 Bridget Street, Danville 24541, VA, USA
Received: 19 August 2013 / Revised: 26 September 2013 / Accepted: 27 September 2013 / Published: 18 October 2013
(This article belongs to the Special Issue Liposome Technologies)
View Full-Text   |   Download PDF [689 KB, uploaded 18 October 2013]   |  

Abstract

Fullerene medicine is a new but rapidly growing research subject. Fullerene has a number of desired structural, physical and chemical properties to be adapted for biological use including antioxidants, anti-aging, anti-inflammation, photodynamic therapy, drug delivery, and magnetic resonance imaging contrast agents. Chemical functionalization of fullerenes has led to several interesting compounds with very promising preclinical efficacy, pharmacokinetic and safety data. However, there is no clinical evaluation or human use except in fullerene-based cosmetic products for human skincare. This article summarizes recent advances in liposome formulation of fullerenes for the use in therapeutics and molecular imaging. View Full-Text
Keywords: fullerene; metallofullerene; liposome; antioxidant; anti-inflammation; photosensitizer; drug delivery; molecular imaging; magnetic resonance imaging fullerene; metallofullerene; liposome; antioxidant; anti-inflammation; photosensitizer; drug delivery; molecular imaging; magnetic resonance imaging
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhou, Z. Liposome Formulation of Fullerene-Based Molecular Diagnostic and Therapeutic Agents. Pharmaceutics 2013, 5, 525-541.

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