Pharmaceutics 2011, 3(1), 88-106; doi:10.3390/pharmaceutics3010088
Article

First Quantitative Imaging of Organic Fluorine within Angiogenic Tissues by Particle Induced Gamma-Ray Emission (PIGE) Analysis: First PIGE Organic Fluorine Imaging

1, 1, 2, 2, 3, 1, 3 and 1,* email
Received: 31 December 2010; in revised form: 28 February 2011 / Accepted: 7 March 2011 / Published: 9 March 2011
(This article belongs to the Special Issue Molecular Imaging)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: PET (Positron Emission Tomography) allows imaging of the in vivo distribution of biochemical compounds labeled with a radioactive tracer, mainly 18F-FDG (2-deoxy-2-[18F] fluoro-D-glucose). 18F only allows a relatively poor spatial resolution (2-3 mm) which does not allow imaging of small tumors or specific small size tissues, e.g. vasculature. Unfortunately, angiogenesis is a key process in various physiologic and pathologic processes and is, for instance, involved in modern anticancer approaches. Thus ability to visualize angiogenesis could allow early diagnosis and help to monitor the response of cancer to specific chemotherapies. Therefore, indirect analytical techniques are required to assess the localization of fluorinated compounds at a micrometric scale. Multimodality imaging approaches could provide accurate information on the metabolic activity of the target tissue. In this article, PIGE method (Particle Induced Gamma-ray Emission) was used to determine fluorinated tracers by the nuclear reaction of 19F(p,p′γ)19F in tissues. The feasibility of this approach was assessed on polyfluorinated model glucose compounds and novel peptide-based tracer designed for angiogenesis imaging. Our results describe the first mapping of the biodistribution of fluorinated compounds in both vascularized normal tissue and tumor tissue.
Keywords: ion beam imaging; fluorine imaging; cancer angiogenesis; tracers peptide synthesis
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MDPI and ACS Style

Lavielle, S.; Gionnet, K.; Ortega, R.; Devès, G.; Kilarski, V.; Wehbe, K.; Bikfalvi, A.; Déléris, G. First Quantitative Imaging of Organic Fluorine within Angiogenic Tissues by Particle Induced Gamma-Ray Emission (PIGE) Analysis: First PIGE Organic Fluorine Imaging. Pharmaceutics 2011, 3, 88-106.

AMA Style

Lavielle S, Gionnet K, Ortega R, Devès G, Kilarski V, Wehbe K, Bikfalvi A, Déléris G. First Quantitative Imaging of Organic Fluorine within Angiogenic Tissues by Particle Induced Gamma-Ray Emission (PIGE) Analysis: First PIGE Organic Fluorine Imaging. Pharmaceutics. 2011; 3(1):88-106.

Chicago/Turabian Style

Lavielle, Sébastien; Gionnet, Karine; Ortega, Richard; Devès, Guillaume; Kilarski, Victor; Wehbe, Katia; Bikfalvi, Andreas; Déléris, Gérard. 2011. "First Quantitative Imaging of Organic Fluorine within Angiogenic Tissues by Particle Induced Gamma-Ray Emission (PIGE) Analysis: First PIGE Organic Fluorine Imaging." Pharmaceutics 3, no. 1: 88-106.

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