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Viruses 2017, 9(6), 150; doi:10.3390/v9060150

Phage-Phagocyte Interactions and Their Implications for Phage Application as Therapeutics

1
Bacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla Street 12, 53-114 Wroclaw, Poland
2
Phage Therapy Unit, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla Street 12, 53-114 Wroclaw, Poland
3
Department of Clinical Immunology, Transplantation Institute, Medical University of Warsaw, Nowogrodzka Street 59, 02-006 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Tessa Quax
Received: 31 March 2017 / Revised: 7 June 2017 / Accepted: 7 June 2017 / Published: 14 June 2017
(This article belongs to the Special Issue Viruses of Microbes)
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Abstract

Phagocytes are the main component of innate immunity. They remove pathogens and particles from organisms using their bactericidal tools in the form of both reactive oxygen species and degrading enzymes—contained in granules—that are potentially toxic proteins. Therefore, it is important to investigate the possible interactions between phages and immune cells and avoid any phage side effects on them. Recent progress in knowledge concerning the influence of phages on phagocytes is also important as such interactions may shape the immune response. In this review we have summarized the current knowledge on phage interactions with phagocytes described so far and their potential implications for phage therapy. The data suggesting that phage do not downregulate important phagocyte functions are especially relevant for the concept of phage therapy. View Full-Text
Keywords: phagocytes; phages; intracellular killing of bacteria; phagocytosis; monocytes; granulocytes; dendritic cells phagocytes; phages; intracellular killing of bacteria; phagocytosis; monocytes; granulocytes; dendritic cells
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Jończyk-Matysiak, E.; Weber-Dąbrowska, B.; Owczarek, B.; Międzybrodzki, R.; Łusiak-Szelachowska, M.; Łodej, N.; Górski, A. Phage-Phagocyte Interactions and Their Implications for Phage Application as Therapeutics. Viruses 2017, 9, 150.

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