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Viruses 2017, 9(6), 148; doi:10.3390/v9060148

Mechanisms of Adaptive Immunity to Porcine Reproductive and Respiratory Syndrome Virus

Department of Veterinary and Biomedical Sciences, University of Minnesota, 1971 Commonwealth Avenue, St. Paul, MN 55108, USA
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Author to whom correspondence should be addressed.
Academic Editors: Linda Dixon and Simon Graham
Received: 31 March 2017 / Revised: 25 May 2017 / Accepted: 7 June 2017 / Published: 13 June 2017
(This article belongs to the Special Issue Porcine Viruses)
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Abstract

The adaptive immune response is necessary for the development of protective immunity against infectious diseases. Porcine reproductive and respiratory syndrome virus (PRRSV), a genetically heterogeneous and rapidly evolving RNA virus, is the most burdensome pathogen of swine health and wellbeing worldwide. Viral infection induces antigen-specific immunity that ultimately clears the infection. However, the resulting immune memory, induced by virulent or attenuated vaccine viruses, is inconsistently protective against diverse viral strains. The immunological mechanisms by which primary and memory protection are generated and used are not well understood. Here, we summarize current knowledge regarding cellular and humoral components of the adaptive immune response to PRRSV infection that mediate primary and memory immune protection against viruses. View Full-Text
Keywords: PRRSV; T cell; B cell; NK cell; neutralizing antibody; porcine; memory; adaptive immune response PRRSV; T cell; B cell; NK cell; neutralizing antibody; porcine; memory; adaptive immune response
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Rahe, M.C.; Murtaugh, M.P. Mechanisms of Adaptive Immunity to Porcine Reproductive and Respiratory Syndrome Virus. Viruses 2017, 9, 148.

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