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Viruses 2017, 9(6), 143; doi:10.3390/v9060143

Zika Virus: Recent Advances towards the Development of Vaccines and Therapeutics

Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Academic Editor: Eric Freed
Received: 18 April 2017 / Revised: 2 June 2017 / Accepted: 8 June 2017 / Published: 13 June 2017
(This article belongs to the Special Issue Advances in Flavivirus Research)
View Full-Text   |   Download PDF [277 KB, uploaded 14 June 2017]

Abstract

Zika is a rapidly emerging public health threat. Although clinical infection is frequently mild, significant neurological manifestations have been demonstrated in infants born to Zika virus (ZIKV) infected mothers. Due to the substantial ramifications of intrauterine infection, effective counter-measures are urgently needed. In order to develop effective anti-ZIKV vaccines and therapeutics, improved animal models and a better understanding of immunological correlates of protection against ZIKV are required. This review will summarize what is currently known about ZIKV, the clinical manifestations and epidemiology of Zika as well as, the development of animal models to study ZIKV infection, host immune responses against ZIKV, and the current state of development of vaccines and therapeutics against ZIKV. View Full-Text
Keywords: Zika virus; animal models; immunology; vaccines; congenital Zika syndrome Zika virus; animal models; immunology; vaccines; congenital Zika syndrome
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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McArthur, M.A. Zika Virus: Recent Advances towards the Development of Vaccines and Therapeutics. Viruses 2017, 9, 143.

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