Protoparvovirus Interactions with the Cellular DNA Damage Response
AbstractProtoparvoviruses are simple single-stranded DNA viruses that infect many animal species. The protoparvovirus minute virus of mice (MVM) infects murine and transformed human cells provoking a sustained DNA damage response (DDR). This DDR is dependent on signaling by the ATM kinase and leads to a prolonged pre-mitotic cell cycle block that features the inactivation of ATR-kinase mediated signaling, proteasome-targeted degradation of p21, and inhibition of cyclin B1 expression. This review explores how protoparvoviruses, and specifically MVM, co-opt the common mechanisms regulating the DDR and cell cycle progression in order to prepare the host nuclear environment for productive infection. View Full-Text
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Majumder, K.; Etingov, I.; Pintel, D.J. Protoparvovirus Interactions with the Cellular DNA Damage Response. Viruses 2017, 9, 323.
Majumder K, Etingov I, Pintel DJ. Protoparvovirus Interactions with the Cellular DNA Damage Response. Viruses. 2017; 9(11):323.Chicago/Turabian Style
Majumder, Kinjal; Etingov, Igor; Pintel, David J. 2017. "Protoparvovirus Interactions with the Cellular DNA Damage Response." Viruses 9, no. 11: 323.
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