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Viruses 2017, 9(12), 359; doi:10.3390/v9120359

Autophagy in Measles Virus Infection

1,2,3,4,5,* , 1,2,3,4,5
and
1,2,3,4,5,6
1
International Center for Infectiology Research (CIRI), Université de Lyon, 69007 Lyon, France
2
Inserm, U1111, 69007 Lyon, France
3
CNRS, UMR5308, 69007 Lyon, France
4
Ecole Normale Supérieure de Lyon, 69007 Lyon, France
5
Université Lyon 1, Centre International de Recherche en Infectiologie, 69007 Lyon, France
6
Equipe FRM Labellisée Fondation Pour la Recherche Médicale FRM, 75007 Paris, France
*
Author to whom correspondence should be addressed.
Received: 5 October 2017 / Revised: 20 November 2017 / Accepted: 22 November 2017 / Published: 24 November 2017
(This article belongs to the Special Issue Viruses and Autophagy)
View Full-Text   |   Download PDF [1138 KB, uploaded 27 November 2017]   |  

Abstract

Autophagy is a biological process that helps cells to recycle obsolete cellular components and which greatly contributes to maintaining cellular integrity in response to environmental stress factors. Autophagy is also among the first lines of cellular defense against invading microorganisms, including viruses. The autophagic destruction of invading pathogens, a process referred to as xenophagy, involves cytosolic autophagy receptors, such as p62/SQSTM1 (Sequestosome 1) or NDP52/CALCOCO2 (Nuclear Dot 52 KDa Protein/Calcium Binding And Coiled-Coil Domain 2), which bind to microbial components and target them towards growing autophagosomes for degradation. However, most, if not all, infectious viruses have evolved molecular tricks to escape from xenophagy. Many viruses even use autophagy, part of the autophagy pathway or some autophagy-associated proteins, to improve their infectious potential. In this regard, the measles virus, responsible for epidemic measles, has a unique interface with autophagy as the virus can induce multiple rounds of autophagy in the course of infection. These successive waves of autophagy result from distinct molecular pathways and seem associated with anti- and/or pro-measles virus consequences. In this review, we describe what the autophagy–measles virus interplay has taught us about both the biology of the virus and the mechanistic orchestration of autophagy. View Full-Text
Keywords: measles virus; autophagy; selective autophagy; autophagy receptors; CD46; IRGM; NDP52; T6BP; OPTN measles virus; autophagy; selective autophagy; autophagy receptors; CD46; IRGM; NDP52; T6BP; OPTN
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Rozières, A.; Viret, C.; Faure, M. Autophagy in Measles Virus Infection. Viruses 2017, 9, 359.

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