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Viruses 2017, 9(10), 280; doi:10.3390/v9100280

An Insight into Cotton Leaf Curl Multan Betasatellite, the Most Important Component of Cotton Leaf Curl Disease Complex

1
National Institute for Biotechnology and Genetic Engineering, 38000 Faisalabad, Pakistan
2
Pakistan Institute of Engineering and Applied Sciences, Nilore, 45650 Islamabad, Pakistan
3
AgroBioChem Department, Gembloux Agro-Bio Tech, University of Liège, 5030 Gembloux, Belgium
4
Boyce Thompson Institute, 533 Tower Rd, Ithaca, NY 14853, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 29 August 2017 / Revised: 20 September 2017 / Accepted: 28 September 2017 / Published: 29 September 2017
(This article belongs to the Special Issue Geminiviruses)
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Abstract

Cotton leaf curl disease (CLCuD) is one of the most economically important diseases and is a constraint to cotton production in major producers, Pakistan and India. CLCuD is caused by monopartite plant viruses belonging to the family Geminiviridae (genus Begomovirus), in association with an essential, disease-specific satellite, Cotton leaf curl Multan betasatellite (CLCuMuB) belonging to a newly-established family Tolecusatellitidae (genus Betasatellite). CLCuMuB has a small genome (ca. 1350 nt) with a satellite conserved region, an adenine-rich region and a single gene that encodes for a multifunctional βC1 protein. CLCuMuB βC1 protein has a major role in pathogenicity and symptom determination, and alters several host cellular functions like autophagy, ubiquitination, and suppression of gene silencing, to assist CLCuD infectivity. Efficient trans-replication ability of CLCuMuB with several monopartite and bipartite begomoviruses, is also associated with the rapid evolution and spread of CLCuMuB. In this article we comprehensively reviewed the role of CLCuMuB in CLCuD, focusing on the βC1 functions and its interactions with host proteins. View Full-Text
Keywords: Cotton leaf curl Multan betasatellite; βC1; begomovirus; leaf curl disease; Gossypium Cotton leaf curl Multan betasatellite; βC1; begomovirus; leaf curl disease; Gossypium
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Zubair, M.; Zaidi, S.S.-E.-A.; Shakir, S.; Amin, I.; Mansoor, S. An Insight into Cotton Leaf Curl Multan Betasatellite, the Most Important Component of Cotton Leaf Curl Disease Complex. Viruses 2017, 9, 280.

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