Next Article in Journal / Special Issue
The Astrovirus Capsid: A Review
Previous Article in Journal
A Semipersistent Plant Virus Differentially Manipulates Feeding Behaviors of Different Sexes and Biotypes of Its Whitefly Vector
Previous Article in Special Issue
Astrovirus Diagnostics
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Viruses 2017, 9(1), 12; doi:10.3390/v9010012

Frequency and Pathological Phenotype of Bovine Astrovirus CH13/NeuroS1 Infection in Neurologically-Diseased Cattle: Towards Assessment of Causality

Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern CH-3012, Switzerland
DCR-VPH, Division of Neurological Sciences, NeuroCenter, University of Bern, Bern CH-3012, Switzerland
Institute of Veterinary Pathology, Vetsuisse-Faculty, University Zurich, Zurich CH-8057, Switzerland
Author to whom correspondence should be addressed.
Academic Editor: Stacey Schultz-Cherry
Received: 30 November 2016 / Revised: 9 January 2017 / Accepted: 12 January 2017 / Published: 18 January 2017
(This article belongs to the Special Issue Astroviruses)
View Full-Text   |   Download PDF [4369 KB, uploaded 18 January 2017]   |  


Next-generation sequencing (NGS) has opened up the possibility of detecting new viruses in unresolved diseases. Recently, astrovirus brain infections have been identified in neurologically diseased humans and animals by NGS, among them bovine astrovirus (BoAstV) CH13/NeuroS1, which has been found in brain tissues of cattle with non-suppurative encephalitis. Only a few studies are available on neurotropic astroviruses and a causal relationship between BoAstV CH13/NeuroS1 infections and neurological disease has been postulated, but remains unproven. Aiming at making a step forward towards assessing the causality, we collected brain samples of 97 cases of cattle diagnosed with unresolved non-suppurative encephalitis, and analyzed them by in situ hybridization and immunohistochemistry, to determine the frequency and neuropathological distribution of the BoAstV CH13/NeuroS1 and its topographical correlation to the pathology. We detected BoAstV CH13/NeuroS1 RNA or proteins in neurons throughout all parts of the central nervous system (CNS) in 34% of all cases, but none were detected in cattle of the control group. In general, brain lesions had a high correlation with the presence of the virus. These findings show that a substantial proportion of cattle with non-suppurative encephalitis are infected with BoAstV CH13/NeuroS1 and further substantiate the causal relationship between neurological disease and astrovirus infections. View Full-Text
Keywords: astrovirus; bovine; encephalitis; neurotropic; infection; cattle astrovirus; bovine; encephalitis; neurotropic; infection; cattle

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Selimovic-Hamza, S.; Boujon, C.L.; Hilbe, M.; Oevermann, A.; Seuberlich, T. Frequency and Pathological Phenotype of Bovine Astrovirus CH13/NeuroS1 Infection in Neurologically-Diseased Cattle: Towards Assessment of Causality. Viruses 2017, 9, 12.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top