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Viruses 2017, 9(1), 12; doi:10.3390/v9010012

Frequency and Pathological Phenotype of Bovine Astrovirus CH13/NeuroS1 Infection in Neurologically-Diseased Cattle: Towards Assessment of Causality

1
Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern CH-3012, Switzerland
2
DCR-VPH, Division of Neurological Sciences, NeuroCenter, University of Bern, Bern CH-3012, Switzerland
3
Institute of Veterinary Pathology, Vetsuisse-Faculty, University Zurich, Zurich CH-8057, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Stacey Schultz-Cherry
Received: 30 November 2016 / Revised: 9 January 2017 / Accepted: 12 January 2017 / Published: 18 January 2017
(This article belongs to the Special Issue Astroviruses)
View Full-Text   |   Download PDF [4369 KB, uploaded 18 January 2017]   |  

Abstract

Next-generation sequencing (NGS) has opened up the possibility of detecting new viruses in unresolved diseases. Recently, astrovirus brain infections have been identified in neurologically diseased humans and animals by NGS, among them bovine astrovirus (BoAstV) CH13/NeuroS1, which has been found in brain tissues of cattle with non-suppurative encephalitis. Only a few studies are available on neurotropic astroviruses and a causal relationship between BoAstV CH13/NeuroS1 infections and neurological disease has been postulated, but remains unproven. Aiming at making a step forward towards assessing the causality, we collected brain samples of 97 cases of cattle diagnosed with unresolved non-suppurative encephalitis, and analyzed them by in situ hybridization and immunohistochemistry, to determine the frequency and neuropathological distribution of the BoAstV CH13/NeuroS1 and its topographical correlation to the pathology. We detected BoAstV CH13/NeuroS1 RNA or proteins in neurons throughout all parts of the central nervous system (CNS) in 34% of all cases, but none were detected in cattle of the control group. In general, brain lesions had a high correlation with the presence of the virus. These findings show that a substantial proportion of cattle with non-suppurative encephalitis are infected with BoAstV CH13/NeuroS1 and further substantiate the causal relationship between neurological disease and astrovirus infections. View Full-Text
Keywords: astrovirus; bovine; encephalitis; neurotropic; infection; cattle astrovirus; bovine; encephalitis; neurotropic; infection; cattle
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MDPI and ACS Style

Selimovic-Hamza, S.; Boujon, C.L.; Hilbe, M.; Oevermann, A.; Seuberlich, T. Frequency and Pathological Phenotype of Bovine Astrovirus CH13/NeuroS1 Infection in Neurologically-Diseased Cattle: Towards Assessment of Causality. Viruses 2017, 9, 12.

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