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Viruses 2016, 8(7), 193; doi:10.3390/v8070193

Determinants of Genomic RNA Encapsidation in the Saccharomyces cerevisiae Long Terminal Repeat Retrotransposons Ty1 and Ty3

1
Laboratory of Structural Chemistry and Biology of Nucleic Acids, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan 61-704, Poland
2
RT Biochemistry Section, Basic Research Laboratory, National Cancer Institute, Frederick, MD 21702, USA
*
Authors to whom correspondence should be addressed.
Academic Editors: Roland Marquet and Polly Roy
Received: 25 May 2016 / Revised: 21 June 2016 / Accepted: 28 June 2016 / Published: 14 July 2016
(This article belongs to the Special Issue RNA Packaging)
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Abstract

Long-terminal repeat (LTR) retrotransposons are transposable genetic elements that replicate intracellularly, and can be considered progenitors of retroviruses. Ty1 and Ty3 are the most extensively characterized LTR retrotransposons whose RNA genomes provide the template for both protein translation and genomic RNA that is packaged into virus-like particles (VLPs) and reverse transcribed. Genomic RNAs are not divided into separate pools of translated and packaged RNAs, therefore their trafficking and packaging into VLPs requires an equilibrium between competing events. In this review, we focus on Ty1 and Ty3 genomic RNA trafficking and packaging as essential steps of retrotransposon propagation. We summarize the existing knowledge on genomic RNA sequences and structures essential to these processes, the role of Gag proteins in repression of genomic RNA translation, delivery to VLP assembly sites, and encapsidation. View Full-Text
Keywords: Ty1 retrotransposon; Ty3 retrotransposon; RNA packaging; RNA trafficking; Gag protein Ty1 retrotransposon; Ty3 retrotransposon; RNA packaging; RNA trafficking; Gag protein
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Pachulska-Wieczorek, K.; Le Grice, S.F.; Purzycka, K.J. Determinants of Genomic RNA Encapsidation in the Saccharomyces cerevisiae Long Terminal Repeat Retrotransposons Ty1 and Ty3. Viruses 2016, 8, 193.

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