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Viruses 2016, 8(6), 165; doi:10.3390/v8060165

The Feat of Packaging Eight Unique Genome Segments

1
Institute of Virology, University Medical Center Freiburg, Hermann-Herder-Strasse 11, 79104 Freiburg, Germany
2
Spemann Graduate School of Biology and Medicine, University of Freiburg, 79104 Freiburg, Germany
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editors: Roland Marquet and Polly Roy
Received: 4 May 2016 / Accepted: 7 June 2016 / Published: 17 June 2016
(This article belongs to the Special Issue RNA Packaging)
View Full-Text   |   Download PDF [1056 KB, uploaded 17 June 2016]   |  

Abstract

Influenza A viruses (IAVs) harbor a segmented RNA genome that is organized into eight distinct viral ribonucleoprotein (vRNP) complexes. Although a segmented genome may be a major advantage to adapt to new host environments, it comes at the cost of a highly sophisticated genome packaging mechanism. Newly synthesized vRNPs conquer the cellular endosomal recycling machinery to access the viral budding site at the plasma membrane. Genome packaging sequences unique to each RNA genome segment are thought to be key determinants ensuring the assembly and incorporation of eight distinct vRNPs into progeny viral particles. Recent studies using advanced fluorescence microscopy techniques suggest the formation of vRNP sub-bundles (comprising less than eight vRNPs) during their transport on recycling endosomes. The formation of such sub-bundles might be required for efficient packaging of a bundle of eight different genomes segments at the budding site, further highlighting the complexity of IAV genome packaging. View Full-Text
Keywords: influenza virus; vRNP; genome packaging; formation of genome sub-bundles; packaging sequences influenza virus; vRNP; genome packaging; formation of genome sub-bundles; packaging sequences
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Giese, S.; Bolte, H.; Schwemmle, M. The Feat of Packaging Eight Unique Genome Segments. Viruses 2016, 8, 165.

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