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Viruses 2016, 8(7), 192; doi:10.3390/v8070192

Coordination of Genomic RNA Packaging with Viral Assembly in HIV-1

Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK
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Author to whom correspondence should be addressed.
Academic Editors: Polly Roy and Roland Marquet
Received: 16 June 2016 / Revised: 4 July 2016 / Accepted: 7 July 2016 / Published: 14 July 2016
(This article belongs to the Special Issue RNA Packaging)
View Full-Text   |   Download PDF [906 KB, uploaded 14 July 2016]   |  

Abstract

The tremendous progress made in unraveling the complexities of human immunodeficiency virus (HIV) replication has resulted in a library of drugs to target key aspects of the replication cycle of the virus. Yet, despite this accumulated wealth of knowledge, we still have much to learn about certain viral processes. One of these is virus assembly, where the viral genome and proteins come together to form infectious progeny. Here we review this topic from the perspective of how the route to production of an infectious virion is orchestrated by the viral genome, and we compare and contrast aspects of the assembly mechanisms employed by HIV-1 with those of other RNA viruses. View Full-Text
Keywords: HIV-1; RNA; packaging; assembly HIV-1; RNA; packaging; assembly
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Hellmund, C.; Lever, A.M.L. Coordination of Genomic RNA Packaging with Viral Assembly in HIV-1. Viruses 2016, 8, 192.

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