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Viruses 2016, 8(2), 32; doi:10.3390/v8020032

The Autophagic Machinery in Enterovirus Infection

Department of Medical Microbiology, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia
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Author to whom correspondence should be addressed.
Academic Editor: George Belov
Received: 29 September 2015 / Revised: 13 January 2016 / Accepted: 19 January 2016 / Published: 27 January 2016
(This article belongs to the Special Issue Recent Progress in Enterovirus Research)
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Abstract

The Enterovirus genus of the Picornaviridae family comprises many important human pathogens, including polioviruses, rhinovirus, enterovirus A71, and enterovirus D68. They cause a wide variety of diseases, ranging from mild to severe life-threatening diseases. Currently, no effective vaccine is available against enteroviruses except for poliovirus. Enteroviruses subvert the autophagic machinery to benefit their assembly, maturation, and exit from host. Some enteroviruses spread between cells via a process described as autophagosome-mediated exit without lysis (AWOL). The early and late phases of autophagy are regulated through various lipids and their metabolizing enzymes. Some of these lipids and enzymes are specifically regulated by enteroviruses. In the present review, we summarize the current understanding of the regulation of autophagic machinery by enteroviruses, and provide updates on recent developments in this field. View Full-Text
Keywords: picornavirus; enterovirus; replication; antiviral; autophagy; lipids; autophagosome maturation picornavirus; enterovirus; replication; antiviral; autophagy; lipids; autophagosome maturation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lai, J.K.F.; Sam, I.-C.; Chan, Y.F. The Autophagic Machinery in Enterovirus Infection. Viruses 2016, 8, 32.

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