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Viruses 2016, 8(1), 22; doi:10.3390/v8010022

Innate Immunity Evasion by Enteroviruses: Insights into Virus-Host Interaction

1
MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology (IPB), Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing 100730, China
2
Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, China
*
Author to whom correspondence should be addressed.
Academic Editor: George Belov
Received: 3 November 2015 / Revised: 16 December 2015 / Accepted: 25 December 2015 / Published: 15 January 2016
(This article belongs to the Special Issue Recent Progress in Enterovirus Research)
View Full-Text   |   Download PDF [1147 KB, uploaded 15 January 2016]   |  

Abstract

Enterovirus genus includes multiple important human pathogens, such as poliovirus, coxsackievirus, enterovirus (EV) A71, EV-D68 and rhinovirus. Infection with EVs can cause numerous clinical conditions including poliomyelitis, meningitis and encephalitis, hand-foot-and-mouth disease, acute flaccid paralysis, diarrhea, myocarditis and respiratory illness. EVs, which are positive-sense single-stranded RNA viruses, trigger activation of the host antiviral innate immune responses through pathogen recognition receptors such as retinoic acid-inducible gene (RIG-I)-likeand Toll-like receptors. In turn, EVs have developed sophisticated strategies to evade host antiviral responses. In this review, we discuss the interplay between the host innate immune responses and EV infection, with a primary focus on host immune detection and protection against EV infection and viral strategies to evade these antiviral immune responses. View Full-Text
Keywords: enteroviruses; innate immune responses; pattern-recognition receptors; antiviral response evasion enteroviruses; innate immune responses; pattern-recognition receptors; antiviral response evasion
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lei, X.; Xiao, X.; Wang, J. Innate Immunity Evasion by Enteroviruses: Insights into Virus-Host Interaction. Viruses 2016, 8, 22.

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