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Viruses 2016, 8(12), 340; doi:10.3390/v8120340

Use of Cellular Decapping Activators by Positive-Strand RNA Viruses

Molecular Virology Laboratory, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona 08003, Spain
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Author to whom correspondence should be addressed.
Academic Editor: J. Robert Hogg
Received: 24 October 2016 / Revised: 6 December 2016 / Accepted: 19 December 2016 / Published: 21 December 2016
(This article belongs to the Special Issue Viral Interactions with Host RNA Decay Pathways)
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Abstract

Positive-strand RNA viruses have evolved multiple strategies to not only circumvent the hostile decay machinery but to trick it into being a priceless collaborator supporting viral RNA translation and replication. In this review, we describe the versatile interaction of positive-strand RNA viruses and the 5′-3′ mRNA decay machinery with a focus on the viral subversion of decapping activators. This highly conserved viral trickery is exemplified with the plant Brome mosaic virus, the animal Flock house virus and the human hepatitis C virus. View Full-Text
Keywords: mRNA decay; positive strand RNA viruses; virus–host interactions mRNA decay; positive strand RNA viruses; virus–host interactions
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Jungfleisch, J.; Blasco-Moreno, B.; Díez, J. Use of Cellular Decapping Activators by Positive-Strand RNA Viruses. Viruses 2016, 8, 340.

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