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Viruses 2016, 8(12), 335; doi:10.3390/v8120335

Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways

Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, CA 92697, USA
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Author to whom correspondence should be addressed.
Academic Editor: Karen Beemon
Received: 5 November 2016 / Revised: 7 December 2016 / Accepted: 9 December 2016 / Published: 20 December 2016
(This article belongs to the Special Issue Viral Interactions with Host RNA Decay Pathways)
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Abstract

To successfully replicate, viruses protect their genomic material from degradation by the host cell. RNA viruses must contend with numerous destabilizing host cell processes including mRNA decay pathways and viral RNA (vRNA) degradation resulting from the antiviral response. Members of the Picornaviridae family of small RNA viruses have evolved numerous diverse strategies to evade RNA decay, including incorporation of stabilizing elements into vRNA and re-purposing host stability factors. Viral proteins are deployed to disrupt and inhibit components of the decay machinery and to redirect decay machinery to the advantage of the virus. This review summarizes documented interactions of picornaviruses with cellular RNA decay pathways and processes. View Full-Text
Keywords: picornavirus; Picornaviridae; poliovirus; coxsackievirus; human rhinovirus; RNA degradation; mRNA decay; RNA stability; RNase L; deadenylase picornavirus; Picornaviridae; poliovirus; coxsackievirus; human rhinovirus; RNA degradation; mRNA decay; RNA stability; RNase L; deadenylase
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ullmer, W.; Semler, B.L. Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways. Viruses 2016, 8, 335.

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