Next Article in Journal
The Use of Convalescent Sera in Immune-Electron Microscopy to Detect Non-Suspected/New Viral Agents
Previous Article in Journal
Dynamics of Apis mellifera Filamentous Virus (AmFV) Infections in Honey Bees and Relationships with Other Parasites
Article Menu

Export Article

Open AccessReview
Viruses 2015, 7(5), 2668-2682; doi:10.3390/v7052668

Nucleocytoplasmic Shuttling of Influenza A Virus Proteins

1,†
,
1,2,†
,
1
and
1,2,*
1
Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
2
University of Chinese Academy of Sciences, Beijing 100049, China
*
Author to whom correspondence should be addressed.
Academic Editor: Alexander Ploss
Received: 24 December 2014 / Accepted: 20 May 2015 / Published: 22 May 2015
View Full-Text   |   Download PDF [770 KB, uploaded 22 May 2015]   |  

Abstract

Influenza viruses transcribe and replicate their genomes in the nuclei of infected host cells. The viral ribonucleoprotein (vRNP) complex of influenza virus is the essential genetic unit of the virus. The viral proteins play important roles in multiple processes, including virus structural maintenance, mediating nucleocytoplasmic shuttling of the vRNP complex, virus particle assembly, and budding. Nucleocytoplasmic shuttling of viral proteins occurs throughout the entire virus life cycle. This review mainly focuses on matrix protein (M1), nucleoprotein (NP), nonstructural protein (NS1), and nuclear export protein (NEP), summarizing the mechanisms of their nucleocytoplasmic shuttling and the regulation of virus replication through their phosphorylation to further understand the regulation of nucleocytoplasmic shuttling in host adaptation of the viruses. View Full-Text
Keywords: influenza A virus; nucleocytoplasmic shuttling; virus replication influenza A virus; nucleocytoplasmic shuttling; virus replication
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Li, J.; Yu, M.; Zheng, W.; Liu, W. Nucleocytoplasmic Shuttling of Influenza A Virus Proteins. Viruses 2015, 7, 2668-2682.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top