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Viruses 2015, 7(4), 1613-1626; doi:10.3390/v7041613

Apigenin Restricts FMDV Infection and Inhibits Viral IRES Driven Translational Activity

State Key Laboratory of Agricultural Microbiology, Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, Hubei, China
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Author to whom correspondence should be addressed.
Academic Editor: Curt Hagedorn
Received: 10 February 2015 / Revised: 4 March 2015 / Accepted: 26 March 2015 / Published: 31 March 2015
(This article belongs to the Section Antivirals & Vaccines)
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Abstract

Foot-and-mouth disease (FMD) is a highly contagious disease of domestic and wild ruminants that is caused by FMD virus (FMDV). FMD outbreaks have occurred in livestock-containing regions worldwide. Apigenin, which is a flavonoid naturally existing in plant, possesses various pharmacological effects, including anti-inflammatory, anticancer, antioxidant and antiviral activities. Results show that apigenin can inhibit FMDV-mediated cytopathogenic effect and FMDV replication in vitro. Further studies demonstrate the following: (i) apigenin inhibits FMDV infection at the viral post-entry stage; (ii) apigenin does not exhibit direct extracellular virucidal activity; and (iii) apigenin interferes with the translational activity of FMDV driven by internal ribosome entry site. Studies on applying apigein in vivo are required for drug development and further identification of potential drug targets against FDMV infection. View Full-Text
Keywords: foot-and-mouth disease virus; Apigenin; Antiviral; Internal ribosome entry site foot-and-mouth disease virus; Apigenin; Antiviral; Internal ribosome entry site
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MDPI and ACS Style

Qian, S.; Fan, W.; Qian, P.; Zhang, D.; Wei, Y.; Chen, H.; Li, X. Apigenin Restricts FMDV Infection and Inhibits Viral IRES Driven Translational Activity. Viruses 2015, 7, 1613-1626.

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