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Viruses 2015, 7(1), 268-284; doi:10.3390/v7010268

Bacteriophage-Derived Vectors for Targeted Cancer Gene Therapy

1
Institute of Clinical and Biomedical Science, University of Exeter Medical School, Exeter, Devon EX1 2LU, UK
2
Phage Therapy Group, Department of Medicine, Burlington Danes Building, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Eric O. Freed
Received: 19 November 2014 / Accepted: 13 January 2015 / Published: 19 January 2015
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Abstract

Cancer gene therapy expanded and reached its pinnacle in research in the last decade. Both viral and non-viral vectors have entered clinical trials, and significant successes have been achieved. However, a systemic administration of a vector, illustrating safe, efficient, and targeted gene delivery to solid tumors has proven to be a major challenge. In this review, we summarize the current progress and challenges in the targeted gene therapy of cancer. Moreover, we highlight the recent developments of bacteriophage-derived vectors and their contributions in targeting cancer with therapeutic genes following systemic administration. View Full-Text
Keywords: bacteriophage; CMV; Grp78; AAVP; HSVtk; RGD4C-AAVP/CMV-HSVtk; RGD4C-AAVP/Grp78-HSVtk; glioblastoma bacteriophage; CMV; Grp78; AAVP; HSVtk; RGD4C-AAVP/CMV-HSVtk; RGD4C-AAVP/Grp78-HSVtk; glioblastoma
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Pranjol, M.Z.I.; Hajitou, A. Bacteriophage-Derived Vectors for Targeted Cancer Gene Therapy. Viruses 2015, 7, 268-284.

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