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Viruses 2015, 7(1), 239-251; doi:10.3390/v7010239

Identification of a Novel Human Rhinovirus C Type by Antibody Capture VIDISCA-454

1
Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, Amsterdam 1105 AZ, the Netherlands
2
Department of Virology, Tehran University of Medical Sciences, Tehran 14176-14411, Iran
3
Department of Virus Genomics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
4
Department of Medical Microbiology, Vaccine and Infectious Disease Institute, University Hospital, Antwerp B-2650, Belgium
Current affiliation: Department of Biology, Memorial University of Newfoundland, St John's, NL A1B 3X9, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Eric O. Freed
Received: 31 October 2014 / Revised: 8 January 2015 / Accepted: 13 January 2015 / Published: 19 January 2015
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Abstract

Causative agents for more than 30 percent of respiratory infections remain unidentified, suggesting that unknown respiratory pathogens might be involved. In this study, antibody capture VIDISCA-454 (virus discovery cDNA-AFLP combined with Roche 454 high-throughput sequencing) resulted in the discovery of a novel type of rhinovirus C (RV-C). The virus has an RNA genome of at least 7054 nt and carries the characteristics of rhinovirus C species. The gene encoding viral protein 1, which is used for typing, has only 81% nucleotide sequence identity with the closest known RV-C type, and, therefore, the virus represents the first member of a novel type, named RV-C54. View Full-Text
Keywords: rhinovirus C54; virus discovery; antibody capture VIDISCA-454 rhinovirus C54; virus discovery; antibody capture VIDISCA-454
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Jazaeri Farsani, S.M.; Oude Munnink, B.B.; Canuti, M.; Deijs, M.; Cotten, M.; Jebbink, M.F.; Verhoeven, J.; Kellam, P.; Loens, K.; Goossens, H.; Ieven, M.; van der Hoek, L. Identification of a Novel Human Rhinovirus C Type by Antibody Capture VIDISCA-454. Viruses 2015, 7, 239-251.

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