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Viruses 2014, 6(7), 2899-2937; doi:10.3390/v6072899

Coat as a Dagger: The Use of Capsid Proteins to Perforate Membranes during Non-Enveloped DNA Viruses Trafficking

Department of Genetics and Microbiology, Faculty of Science, Charles University in Prague, Vinicna 5, 12844, Prague 2, Czech Republic
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Received: 20 February 2014 / Revised: 9 July 2014 / Accepted: 14 July 2014 / Published: 23 July 2014
(This article belongs to the Section Animal Viruses)
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Abstract

To get access to the replication site, small non-enveloped DNA viruses have to cross the cell membrane using a limited number of capsid proteins, which also protect the viral genome in the extracellular environment. Most of DNA viruses have to reach the nucleus to replicate. The capsid proteins involved in transmembrane penetration are exposed or released during endosomal trafficking of the virus. Subsequently, the conserved domains of capsid proteins interact with cellular membranes and ensure their efficient permeabilization. This review summarizes our current knowledge concerning the role of capsid proteins of small non-enveloped DNA viruses in intracellular membrane perturbation in the early stages of infection. View Full-Text
Keywords: viruses; membrane perforation; viroporins; coat protein; capsid protein; polyomavirus; adenovirus; papillomavirus; parvovirus; cell entry; trafficking; endosome escape viruses; membrane perforation; viroporins; coat protein; capsid protein; polyomavirus; adenovirus; papillomavirus; parvovirus; cell entry; trafficking; endosome escape
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Bilkova, E.; Forstova, J.; Abrahamyan, L. Coat as a Dagger: The Use of Capsid Proteins to Perforate Membranes during Non-Enveloped DNA Viruses Trafficking. Viruses 2014, 6, 2899-2937.

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