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Viruses 2014, 6(6), 2268-2286; doi:10.3390/v6062268

The Tumor-Associated Marker, PVRL4 (Nectin-4), Is the Epithelial Receptor for Morbilliviruses

1
The Department of Microbiology and Immunology, Dalhousie University, Halifax, B3H 1X5 NS, Canada
2
IWK Health Centre, Canadian Center for Vaccinology, Goldbloom Pavilion, Halifax, B3H 1X5 NS, Canada
3
The Department of Pediatrics, Dalhousie University, Halifax, B3K 6R8 NS, Canada
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 19 March 2014 / Revised: 14 May 2014 / Accepted: 15 May 2014 / Published: 2 June 2014
(This article belongs to the Special Issue Morbillivirus Infections)
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Abstract

PVRL4 (nectin-4) was recently identified as the epithelial receptor for members of the Morbillivirus genus, including measles virus, canine distemper virus and peste des petits ruminants virus. Here, we describe the role of PVRL4 in morbillivirus pathogenesis and its promising use in cancer therapies. This discovery establishes a new paradigm for the spread of virus from lymphocytes to airway epithelial cells and its subsequent release into the environment. Measles virus vaccine strains have emerged as a promising oncolytic platform for cancer therapy in the last ten years. Given that PVRL4 is a well-known tumor-associated marker for several adenocarcinoma (lung, breast and ovary), the measles virus could potentially be used to specifically target, infect and destroy cancers expressing PVRL4. View Full-Text
Keywords: morbillivirus; measles virus; canine distemper virus; peste des petits ruminants virus; nectin-4; PVRL4; epithelial receptor; cancer morbillivirus; measles virus; canine distemper virus; peste des petits ruminants virus; nectin-4; PVRL4; epithelial receptor; cancer
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Delpeut, S.; Noyce, R.S.; Richardson, C.D. The Tumor-Associated Marker, PVRL4 (Nectin-4), Is the Epithelial Receptor for Morbilliviruses. Viruses 2014, 6, 2268-2286.

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