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Viruses 2014, 6(6), 2242-2258; doi:10.3390/v6062242
Review

Controlling Cytomegalovirus: Helping the Immune System Take the Lead

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Received: 4 February 2014; in revised form: 9 May 2014 / Accepted: 13 May 2014 / Published: 27 May 2014
(This article belongs to the Special Issue Recent CMV Research)
View Full-Text   |   Download PDF [682 KB, updated 30 May 2014; original version uploaded 27 May 2014]
Abstract: Cytomegalovirus, of the Herpesviridae family, has evolved alongside humans for thousands of years with an intricate balance of latency, immune evasion, and transmission. While upwards of 70% of humans have evidence of CMV infection, the majority of healthy people show little to no clinical symptoms of primary infection and CMV disease is rarely observed during persistent infection in immunocompetent hosts. Despite the fact that the majority of infected individuals are asymptomatic, immunologically, CMV hijacks the immune system by infecting and remaining latent in antigen-presenting cells that occasionally reactivate subclinically and present antigen to T cells, eventually causing the inflation of CMV-specific T cells until they can compromise up to 10% of the entire T cell repertoire. Because of this impact on the immune system, as well as its importance in fields such as stem cell and organ transplant, the relationship between CMV and the immune response has been studied in depth. Here we provide a review of many of these studies and insights into how CMV-specific T cells are currently being used therapeutically.
Keywords: Cytomegalovirus (CMV); Adoptive immunotherapy; T cell; immunotherapy; cellular therapy; transplant Cytomegalovirus (CMV); Adoptive immunotherapy; T cell; immunotherapy; cellular therapy; transplant
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Hanley, P.J.; Bollard, C.M. Controlling Cytomegalovirus: Helping the Immune System Take the Lead. Viruses 2014, 6, 2242-2258.

AMA Style

Hanley PJ, Bollard CM. Controlling Cytomegalovirus: Helping the Immune System Take the Lead. Viruses. 2014; 6(6):2242-2258.

Chicago/Turabian Style

Hanley, Patrick J.; Bollard, Catherine M. 2014. "Controlling Cytomegalovirus: Helping the Immune System Take the Lead." Viruses 6, no. 6: 2242-2258.


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