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Viruses 2014, 6(5), 2155-2185; doi:10.3390/v6052155

The DNA Damage Response Induced by Infection with Human Cytomegalovirus and Other Viruses

1
Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 368 Plantation St, Worcester, MA 01605, USA
2
Program in Immunology and Microbiology, University of Massachusetts Medical School, 368 Plantation St, Worcester, MA 01605, USA
*
Author to whom correspondence should be addressed.
Received: 31 January 2014 / Revised: 2 May 2014 / Accepted: 8 May 2014 / Published: 23 May 2014
(This article belongs to the Special Issue Recent CMV Research)
View Full-Text   |   Download PDF [1134 KB, 12 May 2015; original version 12 May 2015]   |  

Abstract

Viruses use different strategies to overcome the host defense system. Recent studies have shown that viruses can induce DNA damage response (DDR). Many of these viruses use DDR signaling to benefit their replication, while other viruses block or inactivate DDR signaling. This review focuses on the effects of DDR and DNA repair on human cytomegalovirus (HCMV) replication. Here, we review the DDR induced by HCMV infection and its similarities and differences to DDR induced by other viruses. As DDR signaling pathways are critical for the replication of many viruses, blocking these pathways may represent novel therapeutic opportunities for the treatment of certain infectious diseases. Lastly, future perspectives in the field are discussed.
Keywords: HCMV; cell cycle; DNA damage response; DDR; ATM HCMV; cell cycle; DNA damage response; DDR; ATM
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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E, X.; Kowalik, T.F. The DNA Damage Response Induced by Infection with Human Cytomegalovirus and Other Viruses. Viruses 2014, 6, 2155-2185.

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