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Viruses 2014, 6(5), 2122-2137; doi:10.3390/v6052122

Oncolytic Virotherapy of Canine and Feline Cancer

1,2,* , 1
1 Department of Biochemistry, University of Wuerzburg, Wuerzburg D-97074, Germany 2 Genelux Corporation, San Diego Science Center, San Diego, CA 92109, USA 3 Department of Radiation Medicine and Applied Sciences, Rebecca and John Moores Comprehensive Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA
* Authors to whom correspondence should be addressed.
Received: 5 March 2014 / Revised: 22 April 2014 / Accepted: 30 April 2014 / Published: 16 May 2014
(This article belongs to the Section Antivirals & Vaccines)
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Cancer is the leading cause of disease-related death in companion animals such as dogs and cats. Despite recent progress in the diagnosis and treatment of advanced canine and feline cancer, overall patient treatment outcome has not been substantially improved. Virotherapy using oncolytic viruses is one promising new strategy for cancer therapy. Oncolytic viruses (OVs) preferentially infect and lyse cancer cells, without causing excessive damage to surrounding healthy tissue, and initiate tumor-specific immunity. The current review describes the use of different oncolytic viruses for cancer therapy and their application to canine and feline cancer.
Keywords: cancer; canine and feline cancer therapy; oncolytic virus; oncolysis cancer; canine and feline cancer therapy; oncolytic virus; oncolysis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Gentschev, I.; Patil, S.S.; Petrov, I.; Cappello, J.; Adelfinger, M.; Szalay, A.A. Oncolytic Virotherapy of Canine and Feline Cancer. Viruses 2014, 6, 2122-2137.

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