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The Evolution of Adenoviral Vectors through Genetic and Chemical Surface Modifications
Viruses 2014, 6(4), 1540-1563; doi:10.3390/v6041540
Review

Peptide-Based Technologies to Alter Adenoviral Vector Tropism: Ways and Means for Systemic Treatment of Cancer

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Received: 10 February 2014; in revised form: 15 March 2014 / Accepted: 20 March 2014 / Published: 2 April 2014
(This article belongs to the Special Issue Adenoviral Vectors)
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Abstract: Due to the fundamental progress in elucidating the molecular mechanisms of human diseases and the arrival of the post-genomic era, increasing numbers of therapeutic genes and cellular targets are available for gene therapy. Meanwhile, the most important challenge is to develop gene delivery vectors with high efficiency through target cell selectivity, in particular under in situ conditions. The most widely used vector system to transduce cells is based on adenovirus (Ad). Recent endeavors in the development of selective Ad vectors that target cells or tissues of interest and spare the alteration of all others have focused on the modification of the virus broad natural tropism. A popular way of Ad targeting is achieved by directing the vector towards distinct cellular receptors. Redirecting can be accomplished by linking custom-made peptides with specific affinity to cellular surface proteins via genetic integration, chemical coupling or bridging with dual-specific adapter molecules. Ideally, targeted vectors are incapable of entering cells via their native receptors. Such altered vectors offer new opportunities to delineate functional genomics in a natural environment and may enable efficient systemic therapeutic approaches. This review provides a summary of current state-of-the-art techniques to specifically target adenovirus-based gene delivery vectors.
Keywords: adaptor protein; adenovirus; chemical modification; gene therapy; peptide ligand; targeting strategy; vector adaptor protein; adenovirus; chemical modification; gene therapy; peptide ligand; targeting strategy; vector
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Reetz, J.; Herchenröder, O.; Pützer, B.M. Peptide-Based Technologies to Alter Adenoviral Vector Tropism: Ways and Means for Systemic Treatment of Cancer. Viruses 2014, 6, 1540-1563.

AMA Style

Reetz J, Herchenröder O, Pützer BM. Peptide-Based Technologies to Alter Adenoviral Vector Tropism: Ways and Means for Systemic Treatment of Cancer. Viruses. 2014; 6(4):1540-1563.

Chicago/Turabian Style

Reetz, Julia; Herchenröder, Ottmar; Pützer, Brigitte M. 2014. "Peptide-Based Technologies to Alter Adenoviral Vector Tropism: Ways and Means for Systemic Treatment of Cancer." Viruses 6, no. 4: 1540-1563.


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