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Clinical Manifestations and Outcomes of West Nile Virus Infection
Viruses 2014, 6(3), 1015-1036; doi:10.3390/v6031015
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B Cell Response and Mechanisms of Antibody Protection to West Nile Virus

1,*  and 2
Received: 17 December 2013 / Revised: 7 February 2014 / Accepted: 8 February 2014 / Published: 3 March 2014
(This article belongs to the Special Issue West Nile Virus)
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Abstract

West Nile virus (WNV) has become the principal cause of viral encephalitis in North America since its introduction in New York in 1999. This emerging virus is transmitted to humans via the bite of an infected mosquito. While there have been several candidates in clinical trials, there are no approved vaccines or WNV-specific therapies for the treatment of WNV disease in humans. From studies with small animal models and convalescent human patients, a great deal has been learned concerning the immune response to infection with WNV. Here, we provide an overview of a subset of that information regarding the humoral and antibody response generated during WNV infection.
Keywords: West Nile virus; flavivirus; humoral immunity; neutralizing antibody; epitopes; therapeutics West Nile virus; flavivirus; humoral immunity; neutralizing antibody; epitopes; therapeutics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Austin, S.K.; Dowd, K.A. B Cell Response and Mechanisms of Antibody Protection to West Nile Virus. Viruses 2014, 6, 1015-1036.

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