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Viruses 2014, 6(11), 4294-4313; doi:10.3390/v6114294

The Insect Microbiome Modulates Vector Competence for Arboviruses

1
Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21205, USA
2
Genome Institute of Singapore, 60 Biopolis Street, #02-01 Genome, Singapore 138672, Singapore
*
Author to whom correspondence should be addressed.
Received: 28 August 2014 / Revised: 31 October 2014 / Accepted: 3 November 2014 / Published: 11 November 2014
(This article belongs to the Special Issue Impact of the Insect Microbiome on Arbovirus Transmission)
View Full-Text   |   Download PDF [544 KB, uploaded 12 May 2015]

Abstract

Diseases caused by arthropod-borne viruses (arboviruses), such as Dengue, West Nile, and Chikungunya, constitute a major global health burden and are increasing in incidence and geographic range. The natural microbiota of insect vectors influences various aspects of host biology, such as nutrition, reproduction, metabolism, and immunity, and recent studies have highlighted the ability of insect-associated bacteria to reduce vector competence for arboviruses and other pathogens. This reduction can occur through mechanisms, such as immune response activation, resource competition, or the production of anti-viral molecules. Studying the interactions between insect vectors and their microbiota is an important step toward developing alternative strategies for arbovirus transmission control. View Full-Text
Keywords: mosquito; Aedes; Culex; arbovirus; innate immunity; microbiota mosquito; Aedes; Culex; arbovirus; innate immunity; microbiota
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Jupatanakul, N.; Sim, S.; Dimopoulos, G. The Insect Microbiome Modulates Vector Competence for Arboviruses. Viruses 2014, 6, 4294-4313.

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