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Flavivirus Entry Receptors: An Update
INSERM U944, CNRS 7212, Laboratoire de Pathologie et Virologie Moléculaire, Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, Paris 75010, France
Institut Universitaire d'Hématologie, Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, Paris 75010, France
Université Paris Diderot, Sorbonne Paris Cité, Hôpital St. Louis, 1 Avenue Claude Vellefaux, Paris 75475, France
* Author to whom correspondence should be addressed.
Received: 8 October 2013; in revised form: 12 December 2013 / Accepted: 12 December 2013 / Published: 30 December 2013
Abstract: Flaviviruses enter host cells by endocytosis initiated when the virus particles interact with cell surface receptors. The current model suggests that flaviviruses use at least two different sets of molecules for infectious entry: attachment factors that concentrate and/or recruit viruses on the cell surface and primary receptor(s) that bind to virions and direct them to the endocytic pathway. Here, we present the currently available knowledge regarding the flavivirus receptors described so far with specific attention to C-type lectin receptors and the phosphatidylserine receptors, T-cell immunoglobulin and mucin domain (TIM) and TYRO3, AXL and MER (TAM). Their role in flavivirus attachment and entry as well as their implication in the virus biology will be discussed in depth.
Keywords: flavivirus; West Nile virus; dengue virus; viral entry; C-type lectin receptor; phosphatidylserine receptors
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Perera-Lecoin, M.; Meertens, L.; Carnec, X.; Amara, A. Flavivirus Entry Receptors: An Update. Viruses 2014, 6, 69-88.
Perera-Lecoin M, Meertens L, Carnec X, Amara A. Flavivirus Entry Receptors: An Update. Viruses. 2014; 6(1):69-88.
Perera-Lecoin, Manuel; Meertens, Laurent; Carnec, Xavier; Amara, Ali. 2014. "Flavivirus Entry Receptors: An Update." Viruses 6, no. 1: 69-88.