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Gene Therapy Strategies for HIV/AIDS: Preclinical Modeling in Humanized Mice
Viruses 2014, 6(1), 1-12; doi:10.3390/v6010001

Stem-Cell-Based Gene Therapy for HIV Infection

 and *
Received: 1 November 2013 / Revised: 16 December 2013 / Accepted: 19 December 2013 / Published: 24 December 2013
(This article belongs to the Special Issue Gene Therapy for Retroviral Infections)
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Abstract: Despite the enormous success of combined anti-retroviral therapy, HIV infection is still a lifelong disease and continues to spread rapidly worldwide. There is a pressing need to develop a treatment that will cure HIV infection. Recent progress in stem cell manipulation and advancements in humanized mouse models have allowed rapid developments of gene therapy for HIV treatment. In this review, we will discuss two aspects of HIV gene therapy using human hematopoietic stem cells. The first is to generate immune systems resistant to HIV infection while the second strategy involves enhancing anti-HIV immunity to eliminate HIV infected cells.
Keywords: hematopoietic stem cell; HIV; gene therapy; CCR5; engineered immunity hematopoietic stem cell; HIV; gene therapy; CCR5; engineered immunity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhen, A.; Kitchen, S. Stem-Cell-Based Gene Therapy for HIV Infection. Viruses 2014, 6, 1-12.

AMA Style

Zhen A, Kitchen S. Stem-Cell-Based Gene Therapy for HIV Infection. Viruses. 2014; 6(1):1-12.

Chicago/Turabian Style

Zhen, Anjie; Kitchen, Scott. 2014. "Stem-Cell-Based Gene Therapy for HIV Infection." Viruses 6, no. 1: 1-12.

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