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Viruses 2013, 5(12), 3119-3141; doi:10.3390/v5123119
Review

Gene Therapy Strategies for HIV/AIDS: Preclinical Modeling in Humanized Mice

 and *
Received: 6 September 2013; in revised form: 4 November 2013 / Accepted: 3 December 2013 / Published: 12 December 2013
(This article belongs to the Special Issue Gene Therapy for Retroviral Infections)
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Abstract: In the absence of an effective vaccine and lack of a complete cure, gene therapy approaches to control HIV infection offer feasible alternatives. Due to the chronic nature of infection, a wide window of opportunity exists to gene modify the HIV susceptible cells that continuously arise from the bone marrow source. To evaluate promising gene therapy approaches that employ various anti-HIV therapeutic molecules, an ideal animal model is necessary to generate important efficacy and preclinical data. In this regard, the humanized mouse models that harbor human hematopoietic cells susceptible to HIV infection provide a suitable in vivo system. This review summarizes the currently used humanized mouse models and different anti-HIV molecules utilized for conferring HIV resistance. Humanized mouse models are compared for their utility in this context and provide perspectives for new directions.
Keywords: gene therapy for HIV/AIDS; humanized mice for HIV gene therapy; stem cell-based gene therapy; anti-HIV RNA-based therapies; new generation humanized mice gene therapy for HIV/AIDS; humanized mice for HIV gene therapy; stem cell-based gene therapy; anti-HIV RNA-based therapies; new generation humanized mice
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Bennett, M.S.; Akkina, R. Gene Therapy Strategies for HIV/AIDS: Preclinical Modeling in Humanized Mice. Viruses 2013, 5, 3119-3141.

AMA Style

Bennett MS, Akkina R. Gene Therapy Strategies for HIV/AIDS: Preclinical Modeling in Humanized Mice. Viruses. 2013; 5(12):3119-3141.

Chicago/Turabian Style

Bennett, Michael S.; Akkina, Ramesh. 2013. "Gene Therapy Strategies for HIV/AIDS: Preclinical Modeling in Humanized Mice." Viruses 5, no. 12: 3119-3141.


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