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Role of Natural Killer and Gamma-Delta T cells in West Nile Virus Infection
Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
Department of Pathology, Sealy Center for Vaccine Development, Center for Biodefense and Emerging Infectious Diseases, and Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA
* Author to whom correspondence should be addressed.
Received: 25 July 2013; in revised form: 30 August 2013 / Accepted: 16 September 2013 / Published: 20 September 2013
Abstract: Natural Killer (NK) cells and Gamma-delta T cells are both innate lymphocytes that respond rapidly and non-specifically to viral infection and other pathogens. They are also known to form a unique link between innate and adaptive immunity. Although they have similar immune features and effector functions, accumulating evidence in mice and humans suggest these two cell types have distinct roles in the control of infection by West Nile virus (WNV), a re-emerging pathogen that has caused fatal encephalitis in North America over the past decade. This review will discuss recent studies on these two cell types in protective immunity and viral pathogenesis during WNV infection.
Keywords: West Nile virus; Natural Killer cells; Gamma-delta T cells
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Cite This Article
MDPI and ACS Style
Wang, T.; Welte, T. Role of Natural Killer and Gamma-Delta T cells in West Nile Virus Infection. Viruses 2013, 5, 2298-2310.
Wang T, Welte T. Role of Natural Killer and Gamma-Delta T cells in West Nile Virus Infection. Viruses. 2013; 5(9):2298-2310.
Wang, Tian; Welte, Thomas. 2013. "Role of Natural Killer and Gamma-Delta T cells in West Nile Virus Infection." Viruses 5, no. 9: 2298-2310.