Viruses 2013, 5(9), 2062-2078; doi:10.3390/v5092062
Review

Recombinant Salmonella enterica Serovar Typhimurium as a Vaccine Vector for HIV-1 Gag

1 Department of Medical Microbiology, University of Zimbabwe, Avondale A178, Harare, Zimbabwe 2 Division of Medical Virology, University of Cape Town, Observatory 7925, Cape Town, South Africa 
Received: 2 June 2013; in revised form: 5 August 2013 / Accepted: 22 August 2013 / Published: 28 August 2013
(This article belongs to the Special Issue AIDS Vaccine 2014)
PDF Full-text Download PDF Full-Text [213 KB, uploaded 28 August 2013 09:28 CEST]
Abstract: The HIV/AIDS epidemic remains a global health problem, especially in Sub-Saharan Africa. An effective HIV-1 vaccine is therefore badly required to mitigate this ever-expanding problem. Since HIV-1 infects its host through the mucosal surface, a vaccine for the virus needs to trigger mucosal as well as systemic immune responses. Oral, attenuated recombinant Salmonella vaccines offer this potential of delivering HIV-1 antigens to both the mucosal and systemic compartments of the immune system. So far, a number of pre-clinical studies have been performed, in which HIV-1 Gag, a highly conserved viral antigen possessing both T- and B-cell epitopes, was successfully delivered by recombinant Salmonella vaccines and, in most cases, induced HIV-specific immune responses. In this review, the potential use of Salmonella enterica serovar Typhimurium as a live vaccine vector for HIV-1 Gag is explored.
Keywords: Salmonella; vaccine; vector; HIV-1 Gag; immune response

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Chin'ombe, N. Recombinant Salmonella enterica Serovar Typhimurium as a Vaccine Vector for HIV-1 Gag. Viruses 2013, 5, 2062-2078.

AMA Style

Chin'ombe N. Recombinant Salmonella enterica Serovar Typhimurium as a Vaccine Vector for HIV-1 Gag. Viruses. 2013; 5(9):2062-2078.

Chicago/Turabian Style

Chin'ombe, Nyasha. 2013. "Recombinant Salmonella enterica Serovar Typhimurium as a Vaccine Vector for HIV-1 Gag." Viruses 5, no. 9: 2062-2078.

Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert