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Viruses 2013, 5(9), 2062-2078; doi:10.3390/v5092062

Recombinant Salmonella enterica Serovar Typhimurium as a Vaccine Vector for HIV-1 Gag

1 Department of Medical Microbiology, University of Zimbabwe, Avondale A178, Harare, Zimbabwe 2 Division of Medical Virology, University of Cape Town, Observatory 7925, Cape Town, South Africa 
Received: 2 June 2013 / Revised: 5 August 2013 / Accepted: 22 August 2013 / Published: 28 August 2013
(This article belongs to the Special Issue AIDS Vaccine 2014)
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The HIV/AIDS epidemic remains a global health problem, especially in Sub-Saharan Africa. An effective HIV-1 vaccine is therefore badly required to mitigate this ever-expanding problem. Since HIV-1 infects its host through the mucosal surface, a vaccine for the virus needs to trigger mucosal as well as systemic immune responses. Oral, attenuated recombinant Salmonella vaccines offer this potential of delivering HIV-1 antigens to both the mucosal and systemic compartments of the immune system. So far, a number of pre-clinical studies have been performed, in which HIV-1 Gag, a highly conserved viral antigen possessing both T- and B-cell epitopes, was successfully delivered by recombinant Salmonella vaccines and, in most cases, induced HIV-specific immune responses. In this review, the potential use of Salmonella enterica serovar Typhimurium as a live vaccine vector for HIV-1 Gag is explored.
Keywords: Salmonella; vaccine; vector; HIV-1 Gag; immune response Salmonella; vaccine; vector; HIV-1 Gag; immune response
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chin'ombe, N. Recombinant Salmonella enterica Serovar Typhimurium as a Vaccine Vector for HIV-1 Gag. Viruses 2013, 5, 2062-2078.

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