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Viruses 2013, 5(9), 2062-2078; doi:10.3390/v5092062
Review

Recombinant Salmonella enterica Serovar Typhimurium as a Vaccine Vector for HIV-1 Gag

1,2
Received: 2 June 2013; in revised form: 5 August 2013 / Accepted: 22 August 2013 / Published: 28 August 2013
(This article belongs to the Special Issue AIDS Vaccine 2014)
View Full-Text   |   Download PDF [213 KB, uploaded 28 August 2013]
Abstract: The HIV/AIDS epidemic remains a global health problem, especially in Sub-Saharan Africa. An effective HIV-1 vaccine is therefore badly required to mitigate this ever-expanding problem. Since HIV-1 infects its host through the mucosal surface, a vaccine for the virus needs to trigger mucosal as well as systemic immune responses. Oral, attenuated recombinant Salmonella vaccines offer this potential of delivering HIV-1 antigens to both the mucosal and systemic compartments of the immune system. So far, a number of pre-clinical studies have been performed, in which HIV-1 Gag, a highly conserved viral antigen possessing both T- and B-cell epitopes, was successfully delivered by recombinant Salmonella vaccines and, in most cases, induced HIV-specific immune responses. In this review, the potential use of Salmonella enterica serovar Typhimurium as a live vaccine vector for HIV-1 Gag is explored.
Keywords: Salmonella; vaccine; vector; HIV-1 Gag; immune response Salmonella; vaccine; vector; HIV-1 Gag; immune response
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chin'ombe, N. Recombinant Salmonella enterica Serovar Typhimurium as a Vaccine Vector for HIV-1 Gag. Viruses 2013, 5, 2062-2078.

AMA Style

Chin'ombe N. Recombinant Salmonella enterica Serovar Typhimurium as a Vaccine Vector for HIV-1 Gag. Viruses. 2013; 5(9):2062-2078.

Chicago/Turabian Style

Chin'ombe, Nyasha. 2013. "Recombinant Salmonella enterica Serovar Typhimurium as a Vaccine Vector for HIV-1 Gag." Viruses 5, no. 9: 2062-2078.



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