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Viruses 2013, 5(9), 2062-2078; doi:10.3390/v5092062
Review

Recombinant Salmonella enterica Serovar Typhimurium as a Vaccine Vector for HIV-1 Gag

1,2
1 Department of Medical Microbiology, University of Zimbabwe, Avondale A178, Harare, Zimbabwe 2 Division of Medical Virology, University of Cape Town, Observatory 7925, Cape Town, South Africa 
Received: 2 June 2013 / Revised: 5 August 2013 / Accepted: 22 August 2013 / Published: 28 August 2013
(This article belongs to the Special Issue AIDS Vaccine 2014)
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Abstract

The HIV/AIDS epidemic remains a global health problem, especially in Sub-Saharan Africa. An effective HIV-1 vaccine is therefore badly required to mitigate this ever-expanding problem. Since HIV-1 infects its host through the mucosal surface, a vaccine for the virus needs to trigger mucosal as well as systemic immune responses. Oral, attenuated recombinant Salmonella vaccines offer this potential of delivering HIV-1 antigens to both the mucosal and systemic compartments of the immune system. So far, a number of pre-clinical studies have been performed, in which HIV-1 Gag, a highly conserved viral antigen possessing both T- and B-cell epitopes, was successfully delivered by recombinant Salmonella vaccines and, in most cases, induced HIV-specific immune responses. In this review, the potential use of Salmonella enterica serovar Typhimurium as a live vaccine vector for HIV-1 Gag is explored.
Keywords: Salmonella; vaccine; vector; HIV-1 Gag; immune response Salmonella; vaccine; vector; HIV-1 Gag; immune response
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Chin'ombe, N. Recombinant Salmonella enterica Serovar Typhimurium as a Vaccine Vector for HIV-1 Gag. Viruses 2013, 5, 2062-2078.

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