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Viruses 2013, 5(8), 1934-1947; doi:10.3390/v5081934

Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif

Institute for Experimental Pathology, University of Iceland, Keldur, 112 Reykjavik, Iceland
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Received: 20 June 2013 / Revised: 19 July 2013 / Accepted: 19 July 2013 / Published: 30 July 2013
(This article belongs to the Special Issue Small Ruminant Lentiviruses)
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Abstract

It is becoming increasingly clear that organisms have developed a variety of mechanisms to fight against viral infection. The viruses have developed means of counteracting these defences in various ways. The APOBEC3 proteins are a mammalian-specific family of nucleic acid cytidine deaminases that block retroviral infection. These inhibitors are counteracted by the Vif proteins encoded by most lentiviruses. In this paper, we will review the interaction of the lentiviral Vif proteins with the APOBEC3 proteins, with an emphasis on sheep APOBEC3 and maedi-visna virus (MVV) Vif.
Keywords: small ruminant lentivirus; maedi-visna virus; APOBEC3; Vif; restriction factors; host defence small ruminant lentivirus; maedi-visna virus; APOBEC3; Vif; restriction factors; host defence
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Jónsson, S.R.; Andrésdóttir, V. Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif. Viruses 2013, 5, 1934-1947.

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