Open AccessThis article is
- freely available
Hepatitis C Virus, Cholesterol and Lipoproteins — Impact for the Viral Life Cycle and Pathogenesis of Liver Disease
Inserm, U1110, Institute of Virology, Strasbourg 67000, France
Université de Strasbourg, Strasbourg 67000, France
Universitaires de Strasbourg, Strasbourg 67000, France
* Author to whom correspondence should be addressed.
Received: 18 March 2013; in revised form: 10 April 2013 / Accepted: 27 April 2013 / Published: 23 May 2013
Abstract: Hepatitis C virus (HCV) is a leading cause of chronic liver disease, including chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Hepatitis C infection associates with lipid and lipoprotein metabolism disorders such as hepatic steatosis, hypobetalipoproteinemia, and hypocholesterolemia. Furthermore, virus production is dependent on hepatic very-low-density lipoprotein (VLDL) assembly, and circulating virions are physically associated with lipoproteins in complexes termed lipoviral particles. Evidence has indicated several functional roles for the formation of these complexes, including co-opting of lipoprotein receptors for attachment and entry, concealing epitopes to facilitate immune escape, and hijacking host factors for HCV maturation and secretion. Here, we review the evidence surrounding pathogenesis of the hepatitis C infection regarding lipoprotein engagement, cholesterol and triglyceride regulation, and the molecular mechanisms underlying these effects.
Keywords: Hepatitis C virus; lipoproteins; apolipoproteins; apoE; apoB; cholesterol; triglyceride; viral attachment; entry; assembly; secretion; viral immune escape; lipid disorder
Article StatisticsClick here to load and display the download statistics.
Notes: Multiple requests from the same IP address are counted as one view.
Cite This Article
MDPI and ACS Style
Felmlee, D.J.; Hafirassou, M.L.; Lefevre, M.; Baumert, T.F.; Schuster, C. Hepatitis C Virus, Cholesterol and Lipoproteins — Impact for the Viral Life Cycle and Pathogenesis of Liver Disease. Viruses 2013, 5, 1292-1324.
Felmlee DJ, Hafirassou ML, Lefevre M, Baumert TF, Schuster C. Hepatitis C Virus, Cholesterol and Lipoproteins — Impact for the Viral Life Cycle and Pathogenesis of Liver Disease. Viruses. 2013; 5(5):1292-1324.
Felmlee, Daniel J.; Hafirassou, Mohamed L.; Lefevre, Mathieu; Baumert, Thomas F.; Schuster, Catherine. 2013. "Hepatitis C Virus, Cholesterol and Lipoproteins — Impact for the Viral Life Cycle and Pathogenesis of Liver Disease." Viruses 5, no. 5: 1292-1324.