Next Article in Journal
Epigenetic Control of Cytomegalovirus Latency and Reactivation
Previous Article in Journal
The Dynamics of HCF-1 Modulation of Herpes Simplex Virus Chromatin during Initiation of Infection
Article Menu

Export Article

Open AccessReview
Viruses 2013, 5(5), 1292-1324; doi:10.3390/v5051292

Hepatitis C Virus, Cholesterol and Lipoproteins — Impact for the Viral Life Cycle and Pathogenesis of Liver Disease

1
Inserm, U1110, Institute of Virology, Strasbourg 67000, France
2
Université de Strasbourg, Strasbourg 67000, France
3
Universitaires de Strasbourg, Strasbourg 67000, France
*
Author to whom correspondence should be addressed.
Received: 18 March 2013 / Revised: 10 April 2013 / Accepted: 27 April 2013 / Published: 23 May 2013
(This article belongs to the Section Animal Viruses)
View Full-Text   |   Download PDF [1013 KB, uploaded 12 May 2015]   |  

Abstract

Hepatitis C virus (HCV) is a leading cause of chronic liver disease, including chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Hepatitis C infection associates with lipid and lipoprotein metabolism disorders such as hepatic steatosis, hypobetalipoproteinemia, and hypocholesterolemia. Furthermore, virus production is dependent on hepatic very-low-density lipoprotein (VLDL) assembly, and circulating virions are physically associated with lipoproteins in complexes termed lipoviral particles. Evidence has indicated several functional roles for the formation of these complexes, including co-opting of lipoprotein receptors for attachment and entry, concealing epitopes to facilitate immune escape, and hijacking host factors for HCV maturation and secretion. Here, we review the evidence surrounding pathogenesis of the hepatitis C infection regarding lipoprotein engagement, cholesterol and triglyceride regulation, and the molecular mechanisms underlying these effects.
Keywords: Hepatitis C virus; lipoproteins; apolipoproteins; apoE; apoB; cholesterol; triglyceride; viral attachment; entry; assembly; secretion; viral immune escape; lipid disorder Hepatitis C virus; lipoproteins; apolipoproteins; apoE; apoB; cholesterol; triglyceride; viral attachment; entry; assembly; secretion; viral immune escape; lipid disorder
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Felmlee, D.J.; Hafirassou, M.L.; Lefevre, M.; Baumert, T.F.; Schuster, C. Hepatitis C Virus, Cholesterol and Lipoproteins — Impact for the Viral Life Cycle and Pathogenesis of Liver Disease. Viruses 2013, 5, 1292-1324.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top