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Viruses 2013, 5(10), 2447-2468; doi:10.3390/v5102447

Non-Structural Proteins of Arthropod-Borne Bunyaviruses: Roles and Functions

1 Department of Botany and Microbiology, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia 2 MRC-University of Glasgow Centre for Virus Research, 8 Church Street, Glasgow G11 5JR, Scotland, UK 3 Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, P.O. Box 7028, Uppsala SE-750 07, Sweden These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 29 July 2013 / Revised: 20 September 2013 / Accepted: 25 September 2013 / Published: 4 October 2013
(This article belongs to the Section Insect Viruses)
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Viruses within the Bunyaviridae family are tri-segmented, negative-stranded RNA viruses. The family includes several emerging and re-emerging viruses of humans, animals and plants, such as Rift Valley fever virus, Crimean-Congo hemorrhagic fever virus, La Crosse virus, Schmallenberg virus and tomato spotted wilt virus. Many bunyaviruses are arthropod-borne, so-called arboviruses. Depending on the genus, bunyaviruses encode, in addition to the RNA-dependent RNA polymerase and the different structural proteins, one or several non-structural proteins. These non-structural proteins are not always essential for virus growth and replication but can play an important role in viral pathogenesis through their interaction with the host innate immune system. In this review, we will summarize current knowledge and understanding of insect-borne bunyavirus non-structural protein function(s) in vertebrate, plant and arthropod.
Keywords: arbovirus; bunyavirus; non-structural protein; host response; virus replication arbovirus; bunyavirus; non-structural protein; host response; virus replication
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Eifan, S.; Schnettler, E.; Dietrich, I.; Kohl, A.; Blomström, A.-L. Non-Structural Proteins of Arthropod-Borne Bunyaviruses: Roles and Functions. Viruses 2013, 5, 2447-2468.

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