Viruses 2013, 5(10), 2447-2468; doi:10.3390/v5102447
Review

Non-Structural Proteins of Arthropod-Borne Bunyaviruses: Roles and Functions

1,†email, 2,†email, 2email, 2email and 2,3,* email
Received: 29 July 2013; in revised form: 20 September 2013 / Accepted: 25 September 2013 / Published: 4 October 2013
(This article belongs to the Section Insect Viruses)
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Abstract: Viruses within the Bunyaviridae family are tri-segmented, negative-stranded RNA viruses. The family includes several emerging and re-emerging viruses of humans, animals and plants, such as Rift Valley fever virus, Crimean-Congo hemorrhagic fever virus, La Crosse virus, Schmallenberg virus and tomato spotted wilt virus. Many bunyaviruses are arthropod-borne, so-called arboviruses. Depending on the genus, bunyaviruses encode, in addition to the RNA-dependent RNA polymerase and the different structural proteins, one or several non-structural proteins. These non-structural proteins are not always essential for virus growth and replication but can play an important role in viral pathogenesis through their interaction with the host innate immune system. In this review, we will summarize current knowledge and understanding of insect-borne bunyavirus non-structural protein function(s) in vertebrate, plant and arthropod.
Keywords: arbovirus; bunyavirus; non-structural protein; host response; virus replication
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Eifan, S.; Schnettler, E.; Dietrich, I.; Kohl, A.; Blomström, A.-L. Non-Structural Proteins of Arthropod-Borne Bunyaviruses: Roles and Functions. Viruses 2013, 5, 2447-2468.

AMA Style

Eifan S, Schnettler E, Dietrich I, Kohl A, Blomström A-L. Non-Structural Proteins of Arthropod-Borne Bunyaviruses: Roles and Functions. Viruses. 2013; 5(10):2447-2468.

Chicago/Turabian Style

Eifan, Saleh; Schnettler, Esther; Dietrich, Isabelle; Kohl, Alain; Blomström, Anne-Lie. 2013. "Non-Structural Proteins of Arthropod-Borne Bunyaviruses: Roles and Functions." Viruses 5, no. 10: 2447-2468.


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