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Transport of the Influenza Virus Genome from Nucleus to Nucleus
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
* Author to whom correspondence should be addressed.
Received: 21 August 2013; in revised form: 24 September 2013 / Accepted: 26 September 2013 / Published: 2 October 2013
Abstract: The segmented genome of an influenza virus is encapsidated into ribonucleoprotein complexes (RNPs). Unusually among RNA viruses, influenza viruses replicate in the nucleus of an infected cell, and their RNPs must therefore recruit host factors to ensure transport across a number of cellular compartments during the course of an infection. Recent studies have shed new light on many of these processes, including the regulation of nuclear export, genome packaging, mechanisms of virion assembly and viral entry and, in particular, the identification of Rab11 on recycling endosomes as a key mediator of RNP transport and genome assembly. This review uses these recent gains in understanding to describe in detail the journey of an influenza A virus RNP from its synthesis in the nucleus through to its entry into the nucleus of a new host cell.
Keywords: influenza virus; nuclear export; intracellular transport; genome packaging; viral entry; nuclear import; NEP; Rab11
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MDPI and ACS Style
Hutchinson, E.C.; Fodor, E. Transport of the Influenza Virus Genome from Nucleus to Nucleus. Viruses 2013, 5, 2424-2446.
Hutchinson EC, Fodor E. Transport of the Influenza Virus Genome from Nucleus to Nucleus. Viruses. 2013; 5(10):2424-2446.
Hutchinson, Edward C.; Fodor, Ervin. 2013. "Transport of the Influenza Virus Genome from Nucleus to Nucleus." Viruses 5, no. 10: 2424-2446.